Chemical Biology Program

The Yueming Li Lab

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Research

Yueming Li, PhD
Yueming Li, PhD


Professor

Research Interests

Basic & Translational research in Cancer and Alzheimer’s disease:
From disease mechanism to therapeutic development.

Research Areas

  • Target Identification & Drug Discovery
  • Chemical Biology & Medicinal Chemistry
  • Biochemistry & Enzymology
  • Biophysics & Structural Biology
  • Animal models & Behavior
  • Neurobiology & Neuroinflammation
  • Autophagy, Protein Aggregation & Clearance

Learn more

Research Projects

The Yueming Li Lab

Featured News

Yueming Li
At Work: Biochemist Yueming Li
Yueming Li aims to develop new agents that inhibit particular intramembrane proteases associated with cancer.
Article
An illustration of a beta-amyloid plaque among the neurons in a brain.
MSK Study Links Inflammation to Alzheimer’s Disease Development
An enzyme that contributes to plaque formation in the brain also serves as a first line of defense against bacteria and viruses, suggesting a link between the two.
Nanotechnology May Aid Diagnosis
Biochemist Yueming Li commented on new technology that is three million times more sensitive at detecting Alzheimer's disease and certain cancers....

Publications Highlights

Nie P, Kalidindi T, Nagle VL, et al. Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe. Clin Cancer Res. 2021;27(22):6145-6155. doi:10.1158/1078-0432.CCR-21-0940

Hur, J.-Y., Frost, G. R., Wu, X., Crump, C., Pan, S. J., Wong, E., … Li, Y.-M. (2020). The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer’s disease. Nature. doi:10.1038/s41586-020-2681-2

Mekala, S., Nelson, G., & Li, Y.-M. Recent developments of small molecule γ-secretase modulators for Alzheimer’s disease. RSC Medicinal Chemistry, 11(9), 1003-1022. doi:10.1039/D0MD00196A (2020)

View All Publications

People

Yueming Li, PhD

Yueming Li, PhD



Professor

  • Dr. Yueming Li studies disease mechanism of Cancer and Alzheimer’s, with the goal of developing novel therapeutics for clinical use.
  • PhD, University of California Berkeley
[email protected]
Email Address
646-888-2194 or 2193
Office Phone

Members

Yueming Li, PhD
Yueming Li

Lab Head

Pascale M. Presendor
Pascale M. Presendor

Administrative Assistant

Pictured: Ji Yeun Hur
Ji Yeun Hur

Senior Research Scientist

Eitan Wong
Eitan Wong

Postdoctoral Fellow

Joanna Zhai
Joanna Zhai

Postdoctoral Fellow

Lauren A. Jonas
Lauren A. Jonas

Graduate Student

Joanna Luo
Joanna Luo

Graduate Student

Pengju Nie
Pengju Nie

Graduate Student

Jessica Falci
Jessica Falci

Graduate Student

Tanya Jain
Tanya Jain

Graduate Student

Zoe Kehs
Zoe Kehs

Graduate student

Chenge Liu
Chenge Liu
Manish Malviya
Manish Malviya

Senior Research Scientist

Shekar Mekala
Shekar Mekala

Senior Research Scientist

Grady Nelson
Grady Nelson

Postdoctoral Fellow

Cyrus Nikain
Cyrus Nikain

Graduate student

Antara Sinha
Antara Sinha

Postdoctoral Fellow

Daniel W. Worroll III
Daniel W. Worroll III

Graduate Student

Lab Alumni
Alissa Brandes
Alissa Brandes

Graduate Student

Courtney Carroll
Courtney Carroll

Graduate Student

Xianzhong Wu, MD, Laboratory Manager
Xianzhong Wu

Laboratory Manager

Danica Chiu
Danica Chiu

Graduate Student

Marilia Barros
Marilia Barros

Postdoctoral Fellow

Natalya Gertsik
Natalya Gertsik

Graduate Student

Qi Liu

Research Fellow

Jessica Pan

Postdoctoral Fellow

David Schachter, Graduate Student
David Schachter

Graduate Student

Georgia Frost
Georgia Frost

Postdoctoral Fellow

Chelsea Paresi
Chelsea Paresi

Graduate Student

Thomas Li
Thomas Li

Graduate Student

George Liao
George Liao

Graduate Student

Courtney Alexander, BS
Courtney Alexander

Graduate Student

Suita Castro
Suita Castro

Research Technician

Deming Chau, PhD
Deming Chau

Postdoctoral Fellow

Jennifer Chien, PhD
Jennifer Chien

Postdoctoral Fellow

Christina J. Crump, BS
Christina J. Crump

Graduate Student

Kelly (Yunke) Guo

Graduate Student

Shan Li

Visiting Student

Jian Luan
Jian Luan

Visiting Scholar

Wenbo Pei
Abhishek Vartak
Abhishek Vartak

Postdoctoral Fellow

Xiaojun Lei

Graduate Student

Yuan Tian

Graduate Student

Lisa Placanica

Graduate Student

Kwangwook Ahn, PhD
Kwangwook Ahn

Research Fellow

C. Chad Shelton

Graduate Student

Lane M. Gilchrist

Sabbatical Professor

Haige Lu, PhD
Haige Lu

Research Fellow

Bhramdeo Bassit

Research Technician

Lei Zhu

Research Fellow

Leonid Tarassishin

Research Fellow

Jiong Chun

Research Fellow

Ingrid Ye Yin

Research Fellow

Lab Affiliations

Open Positions

To learn more about available postdoctoral opportunities, please visit our Career Center

To learn more about compensation and benefits for postdoctoral researchers at MSK, please visit Resources for Postdocs

Career Opportunities

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Get in Touch

Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Yueming Li discloses the following relationships and financial interests:

  • BrightFocus Foundation
    Professional Services and Activities
  • Cure Alzheimer's Fund
    Professional Services and Activities
  • Jiangsu Continental Medical Development Co
    Intellectual Property Rights

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.

This page and data include information for a specific MSK annual disclosure period (January 1, 2022 through disclosure submission in spring 2023). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at [email protected].


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