Memorial Hospital Research Laboratories
The Luke Pike Lab
Research
The Luke Pike Lab seeks to understand the unique biology of brain metastasis (BM) to improve outcomes for patients afflicted with various solid tumors. BM is exceptionally common, with an estimated 400,000 patients diagnosed yearly in the U.S. The mechanisms by which cancer cells spread to and survive in the brain are poorly understood. The standard treatment for BM has been radiation therapy with or without surgical resection, as most drug therapies are ineffective against BM. New drugs, such as immune checkpoint or targeted inhibitors, have shown promising activity against BM, but our understanding of why they often fail in the brain is incomplete. The Pike Lab uses cutting-edge molecular techniques to understand tumor tropism for the brain and to identify features of human BM that might lead to drug or radiation resistance and the survival of cancer cells in the brain tumor microenvironment.
People
Luke Pike, MD, DPhil
- Physician-scientist Luke R.G. Pike studies the mechanistic underpinnings of brain metastasis and seeks to identify translational correlates with outcomes following local or systemic therapy.
- DPhil/PhD, Medical Oncology, University of Oxford
- MD, Yale School of Medicine
- [email protected]
- Email Address
- View physician profile
- Physician profile
Members
Resident Physician, Memorial Sloan Kettering Cancer Center, New York, NY
Memorial Sloan Kettering RO PGY3
Intern
Medical College of Georgia MS3
Project Coordinator
Cornell MS3
Memorial Sloan Kettering RO PGY3
Brown MS2
Undergraduate, University of Miami
Memorial Sloan Kettering RO PGY5
Memorial Sloan Kettering RO PGY4
Harvard Radiation Oncology Program, PGY3
Albert Einstein MS3
Yale Undergrad
Pennsylvania State College of Medicine MS3
Memorial Sloan Kettering RO PGY5
Memorial Sloan Kettering PGY1
Lab Alumni
Memorial Sloan Kettering RO PGY3
Lab Affiliations
Achievements
- Alexander Graham Bell PhD Scholarship (2009)
- The Rhodes Scholarship (2007)