More Information: Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

The Timothy Chan Lab: Publications

Visit PubMed for a full listing of Timothy A. Chan’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Peer-Reviewed Articles

Timothy A. Chan, Heiko Hermeking, Christoph Lengauer, Kenneth W. Kinzler, and Bert Vogelstein (1999) 14-3-3ó is required to prevent mitotic catastrophe following DNA damage. Nature 401, 616-620. (featured article in News & Views)

Tong-chuan He, Timothy A. Chan, Bert Vogelstein, and Kenneth W. Kinzler (1999)PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99, 335-345.

Timothy A. Chan, Paul M. Hwang, Heiko Hermeking, Kenneth W. Kinzler, and Bert Vogelstein (2002) Cooperative effects of genes controlling the G2/M checkpoint. Genes and Development 14, 1584-1588.

Timothy A. Chan, Sabine Glockner, Joo Mi Yi, Wei Chen, Leander Van Neste, Leslie Cope, James G. Herman, Victor Velculescu, Kornel E. Schuebel, Nita Ahuja, Stephen B. Baylin (2008) Convergence of Mutation and Epigenetic Alterations Identifies Common Genes in Cancer that Predict for Poor Prognosis. PLoS Medicine 5 (5).

Timothy A. Chan (2002) Nonsteroidal anti-inflammatory drugs, apoptosis, and colon cancer chemoprevention. Lancet Oncology 3, 166-174.

Timothy A. Chan, Zhenghe Wang, Long H. Dang, Bert Vogelstein, and Kenneth W. Kinzler (2002) Targeted inactivation of CTNNB1 reveals unexpected effects of beta-catenin mutation. Proceedings of the National Academy of Sciences USA 99, 8265-8270.

Timothy A. Chan (2003) Cyclooxygenase inhibition and mechanisms of colorectal cancer prevention. Curr. Cancer Drug Targets 3, 455-63.

Timothy A. Chan, Jon D. Weingart, Michele Parisi, Michael H. Hughes, Alessandro Olivi, Scott Borzillary, Dineli Alahakone, Nicholas A. Detorie, Moody D. Wharam, and Lawrence Kleinberg (2005) Treatment of recurrent glioblastoma multiforme with GliaSite brachytherapy. International Journal of Radiation Oncology, Biology, Physics 62, 1131139.

Timothy A. Chan (2006) Prostaglandins and the Colon Cancer Connection. Trends in Molecular Medicine 12, 240-244.

Timothy A. Chan*, Patrice J. Morin*, Bert Vogelstein, and Kenneth W. Kinzler (1998) Mechanisms underlying nonsteroidal anti-inflammatory drug-induced apoptosis. Proceedings of the National Academy of Sciences USA 95, 681-686.

Timothy Chan (1992) Structure and function of Hydra tyrosine kinase proto oncogenes. BASE 8, 18-28.

Timothy A. Chan, Christian A. Chu, Katheine A. Rauen, Michael Kroiher, Suzanna M. Tatarewicz, and Robert E. Steele (1994) Identification of a gene encoding a novel protein tyrosine kinase containing SH2 domains and ankyrin repeats. Oncogene 9, 1253-1259.

Kornel E. Schuebel, Wei E. Chen, Leslie Cope, Sabine Glockner, Hiromo Suzuki, JooMi Yi, Timothy A. Chan, Leander Van Neste, W. Van Criekinge, et al. (2007). Comparing the DNA hypermethalome with gene mutations in human colorectal cancer. PLoS Genetics 3, 1709-1723.

Paul M. Hwang, Fred Bunz, Jian Yu, Carlo Rago, Timothy A. Chan, Michael P. Murphy, Geoffry F. Kelso, Robin A.J. Smith, Kenneth W. Kinzler, and Bert Vogelstein (2001) Ferredoxin reductase affects p53-dependent, 5-fluorouracil induced apoptosis in colorectal cancer cells. Nature Medicine 7, 1111-1117.

A.T. Ferguson, E. Evron, C.B. Umbricht, T.K. Pandita, Timothy A. Chan, Heiko Hermeking, J.R. Marks, A.R. Lambers, P.A. Futreal, M.R. Stampfer, and Saraswati Sukumar (2000) High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proceedings of the National Academy of Sciences USA 97, 6049-6054.

Hiroyuki Suzuki, Xiaoling Zhou, Jing Yin, Junyi Lei, Hai Yan Jiang, Yukiko Suzuki, Tim Chan, Gregory J. Hannon, Wolfgang J. Mergner, John M. Abraham, and Steven J. Meltzer (1995) Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Human Molecular Genetics 4, 1883-1887.

Xiaoling Zhou, Hiroyuki Suzuki, Junyi Lei, Kristina Cole, Jing Yin, Yukiko Suzuki, John M. Abraham, Yutaka Shimada, Masayuki Imamura, Tim Chan, Gregory J. Hannon, and Stephen J. Meltzer (1996) Growth Suppression of Esophageal Cancer Cells by p16INK4 and p15INK4B in vitro. Cancer J. Sci. Am. 2, 221-225.

Luis T. daCosta, Jin Jen, Tong-chuan He, Timothy A. Chan, Kenneth W. Kinzler, and Bert Vogelstein (1996) Converting cancer genes into killer genes. Proceedings of the National Academy of Sciences USA 93, 4192-4196.

Kohtaro Takei, Timothy A. Chan, Feng-Song Wang, Haiyan Deng, Urs Rutishauser, and Daniel G. Jay (1999) The neural cell adhesion molecules L1 and NCAM-180 act in different steps of neurite outgrowth. The Journal of Neuroscience 19, 9469-9479.

David E. Gerber, Stuart A. Grossman, Timothy A. Chan, and Lawrence E. Kleinberg (2007) Intracranial hemorrhage during GliaSite RTS in a patient receiving anticoagulation. The Journal of Radiotherapy in Practice 6, 53-57.

Chan TA, Collis SJ, Schwaninger JM, DeWeese TL. Elevated mutation frequency in cells heterozygous for Msh2. (submitted)

Lawrence Kleinberg, Geoffrey Yoon, Jon D. Weingart, Michelle Parisi, Alessandro Olivi, Nick A. Detorie, and Timothy A. Chan (2009) Imaging After GliaSite Brachytherapy: Prognostic MRI Indicators of Disease Control and Recurrence. Int J. Radiat Oncol Bio Phys. April 23, 2009.

Wong, J., Armour, E., Kazanzides, P., Iordachita, I., Tryggestad, E., Deng, H., Matinfar, M. Kennedy, C., Liu, Z., Chan T., Gray, O., Verhaegen, F., McNutt, T., DeWeese, TL. (2008) High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities. Int J Radiat Oncol Biol Phys. 71 (5) 1591-9.

Gerber DE, Chan TA. Recent advances in radiation therapy. Am Fam Physician. 2008 Dec 1;78(11):1254-62.

Glöckner SC, Dhir M, Yi JM, McGarvey KE, Van Neste L, Louwagie J, Chan TA, Kleeberger W, de Bruïne AP, Smits KM, Khalid-de Bakker CA, Jonkers DM, Stockbrügger RW, Meijer GA, Oort FA, Iacobuzio-Donahue C, Bierau K, Herman JG, Baylin SB, Van Engeland M, Schuebel KE, Ahuja N. Methylation of TFPI2 in Stool DNA: A Potential Novel Biomarker for the Detection of Colorectal Cancer. Cancer Res. 2009 May 12. [Epub ahead of print]

Veeriah S, Brennan C, Meng S, Singh B, Fagin JA, Solit DB, Paty PB, Rohle D, Vivanco I, Chmielecki J, Pao W, Ladanyi M, Gerald WL, Liau L, Cloughesy TC, Mischel PS, Sander C, Taylor B, Schultz N, Major J, Heguy A, Fang F, Mellinghoff IK, Chan TA. The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proceedings of the National Academy of Science USA 2009.

Meng S, Arbit T, Veeriah S, Mellinghoff IK, Fang F, Vivanco I, Rohle D, Chan TA. 14-3-3sigma and p21 synergize to determine DNA damage response following Chk2 inhibition. Cell Cycle. 2009 Jul 12;8(14). [Epub ahead of print]

Chan TA and Heguy A. The protein tyrosine phosphatase D, a broadly inactivated tumor suppressor regulating STAT function. Cell Cycle 2009, 8(19).

Veeriah S, Taylor BS, Meng S, Fang F, Yilmaz E, Vivanco I, Janakiraman M, Schultz N, Hanrahan AJ, Pao W, Ladanyi M, Sander C, Heguy A, Holland EC, Paty PB, Mischel PS, Liau L, Cloughesy TF, Mellinghoff IK, Solit DB, Chan TA. Somatic mutations of the Parkinson’s disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat Genet. 2009 Nov 29.

Luc Morris, Selvaraju Veeriah, and Timothy A. Chan (2010) Genes at the Interface Between Neurodegeneration and Cancer. Oncogene.

Selvaraju Veeriah, Luc Morris, David Solit, and Timothy A. Chan (2010) The familial Parkinson Disease gene PARK2 is a multisite tumor suppressor on chromosome 6q25.2-27 that regulates cyclin E. Cell Cycle 9.

Miguel A. López-Lago, Venkata J. Thodima, Asha Guttapalli, Timothy A. Chan, Adriana Heguy, Ana M. Molina, Victor E. Reuter, Robert J. Motzer, and Raju S. K. Chaganti (2010) Genomic Deregulation during Renal Cell Carcinoma Metastasis Implements a Myofibroblast-Like Gene Expression Program. Cancer Research 70, 9682-9692.

Fang Fang, Sevin Turcan, Andreas Rimner, Andrew Kaufman, Dilip Giri, Luc G. T. Morris, Ronglai Shen, Venkatraman Seshan, Qianxing Mo, Adriana Heguy, Stephen B. Baylin, Nita Ahuja, Agnes Viale, Joan Massague, Larry Norton, Linda T. Vahdat, Mary Ellen Moynahan, and Timothy A. Chan (2011) Breast Cancer Methylomes Establish an Epigenomic Foundation for Metastasis. Science Translational Medicine 3, 1-12.

Kim J. Png, Mitsukuni Yoshida, Xiang H. F. Zhang, Weiping Shu, Hyeseyng Lee, Andreas Rimner, Timothy A. Chan, Elizabeth Comen, Viktor Andrade, Seok Won Kim, Tari A. King, Cliff Hudis, Larry Norton, James Hicks, Joan Massague, and Sohail F. Tavazoie (2011) MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer. Genes and Development 25, 226-231.

Chan TA, Baylin SB. Epigenetic Biomarkers. Curr Top Microbiol Immunol. 2011 Aug 5. [Epub ahead of print]

Patrick G. Morris, Anne S. Reiner, Olga Rosenvald Szenberg, Jennifer L. Clarke, Katherine S. Panageas, Hector R. Perez, Mark G. Kris, Timothy A. Chan, Lisa M. DeAngelis, Antonio M. Omuro (2011) Leptomeningeal metastasis from non-small cell lung cancer: survival and the impact of whole brain radiotherapy. Journal of Thoracic Oncology 7, 382-385.

Luc G.T. Morris, Barry S. Taylor, Trever G. Binova, Yongxing Gong, Stephanie Eng, Cameron Brennan, Andrew Kaufman, Edward R. Kastenhuber, Victoria E. Banuchi, Bhuvanesh Singh, Adriana Heguy, Agnes Viale, Ingo K. Mellinghoff, Jason Huse, Ian Ganly, and Timothy A. Chan* (2011) Genomic dissection of the EGFR/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers. Proceedings of the National Academy of Sciences USA 108, 19024-19029.

Alan Siu, Joshua J. Wind, Timothy A. Chan, Yoshiya Yamada, Jonathan H. Sherman (2011)  Radiation necrosis following treatment of high grade glioma – a review of the literature and current understanding. Acta Neurochirurgica. Dec 1.

Luc G.T. Morris and Timothy A. Chan* (2011)  Resistance to EGFR inhibitors: molecular determinants and the enigma of head and neck cancer.  Oncotarget 2, 894-895.

Maria C. Pietanza, Kadota K, Huberman K, Sima CS, Fiore JJ, Sumner DK, Travis W, Heguy, A, Ginsberg MS, Holodny AI, Chan TA, Rizvi NA, Azzoli CG, Riely GJ, Kris MG, and Krug LM (2012) Phase II trial of temozolomide in patients with relapsed sensitivity or refractory small cell lung cancer, with assessment of methyl-guanine-DNA methyltransferase as a potential biomarker. Clinical Cancer Research. Jan. 6.

Meehan M, Parthasarathi L, Moran N, Jefferies CA, Foley N, Lazzari E, Murphy D, Ryan J, Ortiz B, Fabius AW, Chan TA, Stallings RA. (2012) Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase a oncogene.  Mol. Cancer 11.

Sevin Turcan, Daniel Rohle, Anuj Goenka, Logan A. Walsh, Fang Fang, Emrullah Yilmaz, Carl Campos, Armida W.M. Fabius, Chao Lu, Patrick S. Ward, Craig B. Thompson, Andrew Kaufman, Olga Guryanova, Ross Levine, Adriana Heguy, Agnes Viale, Luc G.T. Morris, Jason T. Huse, Ingo K. Mellinghoff, and Timothy A. Chan. (2012) IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype.Nature (Feb 15), doi:10.1038/nature10866.

Chao Lu, Patrick S. Ward, Gurpreet S. Kapoor, Dan Rohle, Sevin Turcan, Omar Abdel-Wahab, Christopher Edwards, Raya Khanin, Maria E. Figueroa, Ari Melnick, Kathryn E. Wellen, Donald M. O’Rourke, Shelley L. Berger, Timothy A. Chan, Ross L. Levine, Ingo K. Mellinghoff and Craig B. Thompson. (2012) Impaired histone demethylation contributes to the cell differentiation arrest induced by cancer-associated isocitrate dehydrogenase mutation. Nature (Feb 15), doi:10.1038/nature10860.

Daniel Gorovets, Kasthuri Kannan, Ronglai Shen, Edward Kastenhuber, Nasrin Islamdoubst, Carl Campos, Elena Pentsova, Suresh C. Jhanwar, Adriana Heguy, Ingo K. Mellinghoff, Timothy A. Chan, and Jason Huse. (2012) IDH mutation and neuroglial developmental features define clinically distinct subclasses of lower-grade diffuse astrocytic glioma.Clin Cancer Res. (March 13), doi:10.1158/1078-0432.CCR-11-2977.