Cell Biology Program

The Raju Chaganti Lab

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Research

Pictured: Raju Chaganti
Raju Chaganti, PhD
Emeritus

Professor

The goal of my research program at the Sloan Kettering Institute over the past three decades plus has been the understanding of the natural history of genomic instability in cancer cells and its implication to clinical behavior of tumors on the one hand, and to normal cellular developmental pathways on the other. Over this time period, the tools to identify, measure, and analyze the mechanisms of genomic instability have evolved remarkably.

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Pictured: Raju CHaganti Lab group photo

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Raju Chaganti
At Work: Geneticist Raju Chaganti

Publications

Chaganti, R.S.K., and Nanjangud, G. Cytogenetics of lymphoma. In: Non-Hodgkin’s lymphomas (Mauch, P.M., Armitage, J.O., Coiffier, B., and Dalla-Favera, R., Harris, N.L., eds.) Lippincott, Williams & Wilkins, Baltimore, pp809-824, 2003.

Pasqualucci, L., Migliazza, A., Chaganti, R.S.K., Ye, H. B., and Dalla-Favera, R. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood 101: 2914-2923, 2003.

Teruya-Feldstein, J., Donnelly, G., Goy, A., Hegde, A., Nanjangud, G., Qin, J., Thaler, H., Gillies, F., Dyomin, V.G., Lloyd, K.O., Zelenetz, A.D., Houldsworth, J., and Chaganti, R.S.K. MUC-1 mucin expression correlates with advanced stage disease, adverse event-free and overall survival in diffuse large B-cell lymphoma. Appl. Immunohistochem. Mol. Morph. 11:28-32, 2003.

Houldsworth, J., Olshen, A.B., Cattoretti, G., Donnelly, G.B., Teruya-Feldstein, J., Qin, J., Palanisamy, N., Shen, Y., Dyomina, K., Petlakh, M., Pan, Q., Zelenetz, A.D., and Chaganti, R.S.K. Relationship between REL amplification, REL function, and clinical and biological feaures of diffuse large B-cell lymphoma. Blood. 103: 1862-1868, 2004.

Koul, S., McKiernan, J.M., Narayan, G., Houldsworth, J., Bacik, J., Dobrzynski, D.L., Assad, A.M., Manshukani, M., Reuter, V.E., Bosl, G.J., Chaganti, R.S.K., and Murty, V.V.V.S. Role of promoter hypermethylation in cisplatin treatment response of male germ cell tumors. Mol. Cancer 3:16.

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People

Pictured: Raju Chaganti

Raju Chaganti, PhD

Emeritus

Professor

  • Geneticist Raju Chaganti studies genomic instability in cancer cells and its implications for clinical behavior of tumors and normal cellular developmental pathways.
  • PhD, Harvard University
chagantr@mskcc.org
Email Address
212-639-8121
Office Phone

Members

Nirmala Jagadish, PhD
Nirmala Jagadish

Research Scholar

Ritu Kushwaha, PhD
Ritu Kushwaha

Research Scholar

Miguel Lopez-Lago, PhD
Miguel Lopez-Lago

Research Associate

Rahuldev Malage, PhD
Rahuldev Malage

Research Fellow

Geetu Mendiratta, PhD
Geetu Mendiratta

Research Fellow

Rekha Soni
Rekha Soni

Research Assistant

Lab Affilations

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