More Information: Minus iconIcon indicating subtraction, or that the element can be closed. Plus IconIcon indicating addition, or that the element can be opened. Arrow (down) icon.An arrow icon, usually indicating that the containing element can be opened and closed.

Targeted Therapeutics

By combining tracer amounts of radiolabeled particle therapeutics with dynamic microPET imaging methods, we can sensitively monitor the drug-delivery process and extract key properties relating to the kinetics of cumulative particle tracer uptake. Tumor-specific readouts may be used to estimate therapeutic dosing in the setting of personalized care.

Therapeutic C Dots

Attaching radiolabeled tyrosine kinase inhibitors (TKIs) and chemotherapeutics to C dots enhances treatment efficacy in selective tumor models, while limiting non-specific uptake in the body.

Mesoporous Silica Nanomaterials (MSNs)

To improve efficacy and drug-toxicity profiles, we are using multimodal (PET-optical) MSNs as controlled release platforms for increasing intratumoral localization and retention of therapeutic agents in select tumor models. Novel porous particles, ranging in size from <10 nm to about 150 nm and exhibiting a range of surface charge and pore characteristics, are available to accommodate a variety of therapeutics and to evaluate controlled-release profiles and efficacy.

Melanoma-Selective Radiotherapeutics

By evaluating several small targeting ligands and optimizing the C dot surface chemistry, we are working toward the development of a robust particle radiotherapeutic that can both target and treat certain types of radiosensitive tumors.