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The Michelle Bradbury Lab: Publications

Visit PubMed for a full listing of Michelle S. Bradbury’s journal articles

Pubmed is an online index of biomedical articles maintained by the U.S. National Library of Medicine and the National Institutes of Health.

Peer-Reviewed Articles         

Rosen BR, Belliveau JW, Buchbinder BR, McKinstry RC, Porkka LM, Kennedy DN, Neuder MS, Fisel CR, Aronen HJ, Kwong KK, Weisskoff RM, Cohen MS, and Brady TJ.  Contrast agents and cerebral hemodynamics, Magn Reson Med 1991; 19: 001-008.

Young SW, Sidhu MK, Qing F, Muller HH, Neuder MS, Zanassi G, Mody TD, Hemmi G, Dow W, Mutch JD, Sessler JL, and Miller RA:  Preclinical evaluation of gadolinium (III) texaphyrin [Gd-Tex]:  A new paramagnetic contrast agent for MR imaging, Invest Rad 1994; 29: 330-8.

Cohen FM, Kuwatsuru R, Shames DM, Neuder MS, Mann JS, Vexler VS, Rosenauw W, and Brasch RC.  Contrast-enhanced MRI estimation of altered capillary permeability in experimental mammary carcinomas following x-irradiation, Invest Rad 1994; 29: 970-7.

Kuwatsuru R, Liu T, Cohen FM, Shames DM, Osorio RW, Mann JS, Rosenauw W, Muhler AR, Neuder MS, Robert JP, and Brasch RC.  Acute liver transplantation rejection:  early detection of endothelial leak in a rat model using MRI and a macromolecular contrast media, Invest Rad 1994; 29 (Suppl. No. 2): S297-300.

Brasch RC, Shames DM, Cohen FM, Kuwatsuru R, Neuder MS, Mann JS, Vexler VS, Mugler AR, and Rosenauw W.  Quantitation of capillary permeability to macromolecular MRI contrast media in experimental mammary adenocarcinomas, Invest Rad 1994; 29 (Suppl. No. 2): S8-11.

Bernstein SL, Borst DE, Neuder MS, and Wong P.  Characterization of a human fovea cDNA library and evaluation of putative gene candidates for macular diseases, Genomics 1996; 32: 301-8.

Bradbury MS, Kavanagh PV, Bechtold RE, Chen MY, Ott DJ, and Weber TM.  Mesenteric venous thrombosis: diagnosis and non-invasive imaging. Radiographics, 22(3): 527-541, 2002.

Bradbury MS, Kavanagh PV, Chen MY, Weber TM, and Bechtold RE.  Non-invasive assessment of portomesenteric venous thrombosis: current concepts and imaging strategies, JCAT 2002; 26: 392-404.

Adler LP, Weinberg IN, Bradbury MS, Levine E, Lesko NM, Geisinger K, Berg W, and Freimanis R. Method of combined FDG-PET and radiographic imaging of primary breast cancers. The Breast Journal, 9: 163-166, 2003.

Bradbury M, Hricak H. Molecular MR imaging in oncology. Magn Reson Imaging Clin N Am. 2005 May;13(2):225-40. Review. PubMed

Hou BL, Bradbury MS, Peck KK, Petrovich NM, Gutin PL, and Holodny AI. Effect of Brain Tumor Neovasculature defined by rCBV on BOLD fMRI Activation Volume in the Primary Motor Cortex. NeuroImage, 32: 489-497, 2006.

Barberi T, Bradbury MS, Dinzer Z, Panagiotakos G, Socci N, and Studer L. Derivation of Engraftable Skeletal Myoblasts from Human Embryonic Stem Cells. Nature Medicine, 13: 642-648, 2007.

Bradbury MS, Panagiotakos G, Tomishima M, Zanzonico P, Vider J, Ponomarev V, Chan B, Studer L, and Tabar V. Optical bioluminescence imaging of human ES cell progeny in the rodent CNS. J Neurochem, 102:2029-2039, 2007.

Panagiotakos G, Al Shamy G, Chan B, Abrams R, Greenberg E, Saxena A, Bradbury MS, Gutin P, and Tabar V. The long-term impact of whole brain irradiation on the stem cell and oligodendrocyte precursor compartments PLoS One. 2: e588, 2007.

Bradbury MS, Hambardzumyan D, Zanzonico P, Schwartz J, Cai S, Burnazi E, Larson  SM, and Holland EC. Dynamic Small-Animal PET Imaging of Tumor Proliferation with 3′-Deoxy-3′-18F Fluorothymidine in a Genetically Engineered Mouse Model of High-Grade Gliomas. J Nucl Med, 49: 422-429, 2008.

Peck K, Bradbury MS, Petrovich N, Hou B, Brennan C, Tabar V, and Holodny A.  Presurgical Language fMRI in Brain Tumor Patients with Prior Surgery. Neurosurgery 64:1-9, 2009.

Peck K, Bradbury MS, Hou B, Petrovich N, and Holodny A.  The Role of the Supplementary Motor Area (SMA) in the Execution of Primary Motor Activities in Brain Tumor Patients: Functional MRI Detection of Time-Resolved Differences in the Hemodynamic Response. Med Sci Monit, 15: MT55-62, 2009.

Peck KK, Bradbury MS, Psaty EL, Petrovich N, and Holodny AI. Joint Activation of SMA and pre-SMA during Simultaneous Motor and Language fMRI. NeuroReport 20: 487-491, 2009.

Burns A, Vider J, Ow H, Herz E, Penate-Medina O, Baumgart M, Larson S, Wiesner U, and Bradbury MS. Fluorescent Silica Nanoparticles with Efficient Urinary Excretion for Nanomedicine. Nano Letters, 9: 442-448, 2009.

Suteewong T, Sai H, Lee J, Bradbury M, Hyeon T, Gruner S, and Wiesner U. Ordered Mesoporous Silica Nanoparticles with and without Embedded Iron Oxide Nanoparticles: Structure Evolution during Synthesis, J. Mater. Chem, 20: 7807-7814, 2010.

Suteewong T, Sai H, Cohen R, Wang S, Bradbury M, Baird B, Gruner S, and Wiesner, U. Highly Aminated Mesoporous Silica Nanoparticles with Cubic Pore Structure, J. Am. Chem. Soc., 133: 172-175, 2011.

Pitter KL, Galbán CJ, Galbán S, Saeed-Tehrani O, Li F, Charles N, Bradbury MS, Becher OJ, Chenevert TJ, Rehemtulla A, Ross B, Holland E, Hambardzumyan D.  Perifosine and CCI 779 co-operate to induce cell death and cell cycle arrest in PTEN-intact and PTEN-deficient PDGF-driven mouse high-grade glioma. PLoS ONE 6: e14545, 2011.

Penate Medina O, Haikola M, Tahtinen M, Simpura I, Kaukinen S, Valtanen H, Zhu Y, Wei C, Reunanen J, Nurminen T, Smith-Jones P, Bradbury M, Larson S, Kairemo K. Liposomal tumor targeting in drug delivery and imaging using MMP-2 and MMP-9 binding ligands, J Drug Delivery 2011: 1-9, 2011.

Zinn KR, Anderson CJ, Bradbury M, Cutler CS, Peterson TE, Morgan DE, Price JC, Graham MM, Wittstrom K, Norenberg JP. Components of a curriculum for molecular imaging scientists. J. Nucl Med 52:650-656, 2011.

Benezra M*, Penate-Medina O*, Zanzonico P, Schaer D, Ow H, Burns A, De Stanchina E, Longo V, Herz E, Iyer S, Wolchok J, Larson S, Wiesner U, and Bradbury MS. Multimodal Silica Nanoparticles are Effective Cancer Targeted Probes in a Model of Human Melanoma. J Clin Invest 121:2768-2780, 2011 (*co-first authors)

Benezra M, Phillips E, Butler J, Dobrenkov K, Siim B, Chaplin D, Rafii S, Rabbany S, and Bradbury MS. Monitoring of Human Systemic and Xenograft Models of Leukemia Using a Novel Vascular Disrupting Agent. Leukemia 26: 1771-1778, 2012.

Benezra M, Hambardzumyan D, Penate-Medina O, Pillarsetty K, Veach D, Smith-Jones P, Zanzonico P, Phillips E, Ozawa T, Longo V, Holland E, Larson S, and Bradbury MS. Fluorine-labeled Dasatinib Nanoformulations as Novel Targeted Molecular Imaging Probes in PDGFR-expressing Transgenic High Grade Glioma Models. Neoplasia 14:1132-1143, 2012.

Suteewong T, Sai H, Bradbury MS, Estroff L, Gruner S, Wiesner U. Synthesis and Formation Mechanism of Aminated Mesoporous Silica Nanoparticles. Chem Mater 24: 3895-3905, 2012.

Bradbury MS, Phillips E, Montero P, Cheal S, Stambuk H, Durack J, Sofocleous CT, Meester RJC, Wiesner U, and Patel S. Clinically-Translated Silica Nanoparticles as Dual-Modality Cancer-Targeted Probes for Image-Guided Surgery and Interventions. Integr Biol 5: 74 – 86, 2013.

Suteewong T, Sai H, Hovden R, Muller D, Bradbury MS, Gruner S, Wiesner U. Multicompartment Mesoporous Silica Nanoparticles with Branched Shapes: An Epitaxial Growth Mechanism. Science 340: 337–341, 2013.

Gendelman HE, Balogh LP, Bawa R, Bradbury M, Chang EH, Chiu W, Farokhzad O, Foldvari M, Lanza G, Wang K. The 4th Annual Meeting of the American Society of Nanomedicine. J Neuroimmune Pharmacol. 9: Suppl 1:S1-3, 2014.

Phillips E, Penate-Medina O, Zanzonico PB, Carvajal RD, Mohan P, Ye Y, Humm J, Kaliagian H, Schöder H, Strauss W, Larson SM, Wiesner U, and Bradbury MS. Clinical Translation of an Ultrasmall Optical Hybrid Nanoparticle Probe. Sci. Transl. Med., 6: 260ra149, 2014.

Gabizon A, Bradbury MS, Bedian V, Prabhakar U, Zamboni W, Libutti S, and Grodzinski P.  Cancer nanomedicines- crossing the chasm. Lancet, 384: 2175-2176, 2014.

Suteewong T, Ma K, Drews J, Werner-Zwanziger U, Wiesner U, Bradbury MS. Highly Fluorescent Sub 40-nm Aminated Mesoporous Silica Nanoparticles. J. Sol-Gel. Sci. Technol., 74:32–38, 2015.

Benezra M, Phillips E, Overholtzer M, Zanzonico P, Tuominin E, Wiesner U, and Bradbury MS. Ultrasmall Integrin-Targeted Silica Nanoparticles Modulate Signaling Events and Cellular Processes in a Concentration-Dependent Manner. Small, 11: 1721–1732, 2015.

Bradbury MS. Intraoperative Imaging. Cancer Nanotechnology Plan. Office of Cancer Nanotechnology Research, Center for Strategic Scientific Initiatives, National Cancer Institute, National Institutes of Health, 36-42, 2015.

Yoo B, Ma K, Zhang L, Burns A, Sequeira S, Mellinghoff I, Brennan C, Wiesner U* and Bradbury MS*.  Ultrasmall Dual-Modality Nanoparticle Drug Conjugates Bioorg Med Chem. 23: 7119-30, 2015 (*co-senior authors)

Bradbury MS, Pauliah M, P. Zanzonico, Wiesner U, and Patel S. Intraoperative mapping of SLN metastases using a clinically translated ultrasmall silica nanoparticles. Wiley Interdiscip Rev Nanomed Nanobiotechnol., 2015 (in press)

Kim SE, Zhang L, Ma K, Gao M, Jiang X, Monette S, Mohan P, Gonen M, Zanzonico P, Quinn T, Wiesner U, Overholtzer M*, and Bradbury MS*.  Ultrasmall Nanoparticles Induce Ferroptosis of Nutrient-Deprived Cancer Cells and Suppress Tumor Growth (revised submission, Nat. Nanotech.) (*co-senior authors)

Books, book chapters and reviews

Chen MY and Bradbury MS.  Scope of Diagnostic Imaging.  In: Chen MYM, Pope TL, and Ott DJ, eds.  Basic Radiology.  New York: McGraw-Hill, 2004:1-12.

Bradbury MS and Williams DW.  The Brain and Its Coverings. In: Chen MYM, Pope TL, and Ott DJ, eds. Basic Radiology. New York:  McGraw-Hill, 2004:317-351.

Hricak HH, Akin O, Bradbury MS, Liberman L, Schwartz L, and Larson S. Advanced Imaging Methods. In: DeVita VT, Hellman S, and Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 7th ed. Philadelphia:  Lippincott Williams & Wilkins, 2004:1-29.

Bradbury MS and Gutin PH. Associations among magnetic resonance spectroscopy, apparent diffusion coefficients, and image-guided histopathology [Letter]. Neurosurgery 2004; 54(5):1118-1119.

Bradbury MS and Hricak HH. Molecular Magnetic Resonance Imaging in Oncology: Future Directions. In: Martin DR, ed. MR Imaging Clinics of North America. Philadelphia:  W.B. Saunders Co, 2005;225-240.

Bradbury MS and Gutin PH. The potential of ferumoxytol nanoparticle magnetic resonance imaging, perfusion, and angiography in central nervous system malignancy: A pilot study [Letter]. Neurosurgery 2007; 60(4):601-612.

Bradbury MS, Hricak HH, and Heath JR. Systems Biology and Nanotechnology: Linking Cancer Biology and Imaging. In: Reiser MF, Semmler W, and Hricak H, eds. Magnetic Resonance Tomography. Berlin and Heidelberg: Springer-Verlag, November 2007.

Zapadka ME, Bradbury MS, and Williams DW.  The Brain and Its Coverings. In: Chen MYM, Pope TL, and Ott DJ, eds. Basic Radiology. 2nd ed. New York: McGraw-Hill, 2010

Bradbury MS, The Role of Molecular Imaging in Personalized Medicine. In: Faro S and Mohamed FB, eds. Functional Neuroradiology: Principles and Clinical Applications. Springer, 2011.

Bradbury MS, Mohan Pauliah, and Wiesner U. Ultrasmall Fluorescent Silica Nanoparticles as Intraoperative Imaging Tools for Cancer Diagnosis and Treatment. In: Fong Y and Lewis J, (Editors). The Modern Operating Room: Changing Role of Imaging and Visualization in Surgery. Springer, 2014.

Bradbury MS First-in-human Molecular Targeting and Cancer Imaging using Ultrasmall Dual-Modality C dots.  In:  R. Bawa, G. Audette and I. Rubinstein. (Editors): Handbook of Clinical Nanomedicine: Nanoparticles, Imaging, Therapy and Clinical Applications, Chapter 19, Pan Stanford Publishing, Singapore, 2015.