Rachana Maniyar, PhD

Research Fellow

Rachana Maniyar, PhD

Research Fellow

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Rachana Maniyar

Immunotherapy using anti-CTLA-4 and anti-PD-1 has been successful in clinic, however not all patients respond to these therapies. Thus, we need to find treatment ways to enhance response rates and treatment efficacies and overcome resistance. My work focuses on assessing the efficacy of co-stimulation using agonist antibodies such as anti-GITR, and checkpoint blockade using antagonist antibodies against PD-1 and CTLA-4. I am interested in delineating the factors involved in the success and failure of these therapies; in particular the metabolic interplay between the tumor and the infiltrating immune cells.