I received my B.S. degree from Department of Biology of the M.V. Lomonosov Moscow State University, ranked as the best university in Russia. I completed my Ph.D. at the A. N. Bach Institute of Biochemistry and the Institute of Protein Research, the top-ranked research institutions of the Russian Academy of Sciences, where I acquired a broad knowledge of protein biochemistry and received training in molecular biology.
After coming to USA, I decided to switch from microbiology and protein biochemistry to cancer research and joined Memorial Sloan Kettering Cancer Center (MSK) as a postdoctoral fellow in Dr. Blasberg’s lab in 2001. During my postdoctoral studies and participation in the In Vivo Cellular and Molecular Imaging Center (ICMIC) at MSK, I became professionally competent in cancer cell biology and molecular imaging. My research interests are centered on using various imaging modalities to explore and understand the complexity of the tumor biology.
For over 15 years, my research was focused on the cancer metabolic reprogramming. I proposed and developed several molecular imaging approaches to monitor the temporal dynamics and spatial heterogeneity of hypoxia-inducible factor-1 (HIF-1) activity in tumor-bearing living mice (Serganova et al., Cancer Research, 2004). We also showed the time-dependent accumulation and degradation of the HIF-1α protein with greater sensitivity by using bioluminescence imaging. We were able to better evaluate the differences in subcellular localization and clearance of the HIF-1α fusion protein in both normal and tumor cells using immunofluorescence imaging (Moroz E et al., PLoS One, 2009).
In parallel, I extended my interest in the tumor metabolism toward understanding of the role of lactate and LDH-A on tumor growth and the development of metastases (Serganova et al., Clinical Cancer Research, 2011; Rizwan A, Serganova I et al., Clinical Cancer Research, 2013); a collaboration between the Blasberg and Koutcher labs at MSK.