Kristian Helin: Publications

The Kristian Helin Lab
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Kristian Helin: Publications

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Radzisheuskaya A, Shliaha PV, Grinev V, Lorenzini E, Kovalchuk S, Shlyueva D, Gorshkov V, Hendrickson RC, Jensen ON, Helin K. PRMT5 methylome profiling uncovers a direct link to splicing regulation in acute myeloid leukemia. Nat Struct Mol Biol. 2019 Nov;26(11):999-1012. doi: 10.1038/s41594-019-0313-z. Epub 2019 Oct 14.

Højfeldt JW, Hedehus L, Laugesen A, Tatar T, Wiehle L, Helin K. Non-core Subunits of the PRC2 Complex Are Collectively Required for Its Target-Site Specificity. Mol Cell. 2019 Nov 7;76(3):423-436.e3. doi: 10.1016/j.molcel.2019.07.031. Epub 2019 Sep 11.
 

Rasmussen KD, Berest I, Keβler S, Nishimura K, Simón-Carrasco L, Vassiliou GS, Pedersen MT, Christensen J, Zaugg JB, Helin KTET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells. Genome Res. 2019 Apr;29(4):564-575. doi: 10.1101/gr.239277.118. Epub 2019 Feb 22.

Højfeldt J, Laugesen A, Willumsen BM, Damhofer H, Hedehus L, Tvardovskiy A, Mohammad F, Jensen ON & Helin K. Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2. Nature Structural & Molecular Biology. (2018)

Mohammad F, Weissmann S, Leblanc B, Pandey DP, Højfeldt, JW, Comet I, Zheng C, Johansen JV, Rapin N, Porse BT, Tvardovskiy A, Jensen ON, Olaciregui NG, Lavarino C, Suñol M, de Torres C, Mora J, Carcaboso AM & Helin K. EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas. Nature Medicine 4, 483-492, doi: 10.1038/nm.4293 (2017).

Agger K, Miyagi S, Pedersen MT, Kooistra SM, Johansen JV & Helin K. Jmjd2/Kdm4 demethylases are required for expression of Il3ra and survival of acute myeloid leukemia cells. Genes & Development 30, 1278-1288, doi:10.1101/gad.280495.116 (2016).

Pedersen MT*, Kooistra SM*, Radzisheuskaya A, Laugesen A, Johansen JV, Hayward DG, Nilsson J, Agger K & Helin K. Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development. The EMBO Journal 35, 1550-1564, doi:10.15252/embj.201593317 (2016).

Rasmussen KD, Jia G, Johansen JV, Pedersen MT, Rapin N, Bagger FO, Porse BT, Bernard OA, Christensen J & Helin K. Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis. Genes & Development 29, 910-922, doi:10.1101/gad.260174.115 (2015).

Riising EM, Comet I, Leblanc B, Wu X, Johansen JV & Helin K. Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide. Molecular Cell 55, 347-360, doi:10.1016/j.molcel.2014.06.005 (2014).

Wu X, Johansen JV & Helin K. Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation. Molecular Cell 49, 1134-1146, doi:10.1016/j.molcel.2013.01.016 (2013).

Williams K, Christensen J, Pedersen MT, Johansen JV, Cloos PA, Rappsilber J & Helin K. TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature, 473, 343-8.

Pasini D, Cloos PA, Walfridsson J, Olsson L, Bukowski JP, Johansen JV, Bak M, Tommerup N, Rappsilber J & Helin K (2010). JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells. Nature 464, 306-310.

Selected recent reviews

Laugesen A, Højfeldt JW, Helin KMolecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation. Mol Cell. 2019 Apr 4;74(1):8-18. doi: 10.1016/j.molcel.2019.03.011. Review.

Mohammad F & Helin K. Oncohistones: drivers of pediatric cancers. Genes and Development 23-24, 2313-2324. (2017).

Comet I, Riising E, Leblanc B & Helin K. Maintaining cell identity: PRC2 regulation of transcription and cancer. Nature Reviews Cancer 12, 803-810 (2016).

Rasmussen KD & Helin K. Role of TET enzymes in DNA methylation, development, and cancer. Genes & development 30, 733-750 (2016).