Primary cilia are microtubule-based organelles that extend from the surface of most vertebrate cells. Our lab showed that Hedgehog signaling in mammals depends on this organelle. We study how this organelle controls Hedgehog signaling and the mechanisms that control cilia formation
We study mutations that affect the morphogenetic events of gastrulation to learn how intercellular signals are coupled to cell behavior during the establishment of the body plan. We also study how these genes affect tumor formation and metastasis in the adult.