Human Oncology & Pathogenesis Program

The Jedd Wolchok Lab

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Research

Pictured: Jedd Wolchok
Jedd D. Wolchok, MD, PhD, FASCO
Chief, Immuno-Oncology Service, Human Oncology and Pathogenesis Program

Professor

The overall goals of my laboratory efforts are to develop and implement new ways to use the immune system to treat cancer.

Some of our ongoing projects include:

  • Investigation of the GITR pathway as it relates to regulatory and effector T cells.
  • Use of OX40 agonists alone and in combination with chemotherapy.
  • Exploration of the role of myeloid derived suppressor cells in tumor immunity.
  • Studying of the mechanisms underlying coordinated regulation of myeloid cells and IDO in the tumor environment and their therapeutic relevance.
  • Role of CD47 in T cell signaling.
  • Developing optimal cancer vaccine strategies in pre-clinical mouse models.
  • Role of exercise in immune checkpoint blockade.

We are also closely aligned with the Ludwig Center for Cancer Immunity and work closely with that group to monitor immune responses in patients receiving experimental immunotherapy treatments.

The Jedd Wolchok Lab

Publications

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People

Pictured: Jedd Wolchok

Jedd D. Wolchok, MD, PhD, FASCO

Chief, Immuno-Oncology Service, Human Oncology and Pathogenesis Program

Professor

  • Physician-scientist Jedd Wolchok investigates novel approaches for cancer immunotherapy and mechanisms of tumor cell–immune cell interactions. He has been at the forefront of cancer immunotherapy, as an active clinician scientist exploring innovative immunotherapeutic strategies in laboratory models and as a principal investigator in numerous pivotal clinical trials.
  • Princeton University, Princeton, NJ BA
  • New York University, New York, NY MS
  • New York University, New York, NY PhD
  • New York University, New York, NY MD
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Physician profile

Members

Jedd D. Wolchok, MD, PhD, FASCO
Jedd D. Wolchok

Lab Head

Taha Merghoub, PhD
Taha Merghoub

Attending Biologist

Beatrice Yin, MA
Beatrice Yin

Research Lab Manager

Daniel Hirschhorn-Cymerman

Senior Research Scientist

Sadna Budhu, PhD
Sadna Budhu

Research Associate

Roberta Zappasodi, PhD
Roberta Zappasodi

PICI Bridge Scholar

Isabell Schulze
Isabell Schulze

Research Associate

Hyejin Choi, PhD
Hyejin Choi

Research Associate

Mathieu Gigoux

Research Fellow

Chien-Huan Weng

Research Fellow

Judith Michels, MD, PhD
Judith Michels

Research Fellow

Levi Mark Bala Mangarin, BS
Levi Mark Bala Mangarin

Bioinformatics Technician

Shakuntala Tiwari
Shakuntala Tiwari

Senior Research Assistant

Cailian Liu

Senior Research Assistant

Hong Zhong
Hong Zhong

Senior Research Technician

Xia Yang
Xia Yang

Senior Research Technician

Mohsen Abu-Akeel

Research Technician

Aliya Holland
Aliya Holland

Research Technician

Sara  Schad
Sara Schad

PhD Graduate Student

Lauren Dong
Lauren Dong

PhD Graduate Student

Dmitriy Zamarin, MD, PhD
Dmitriy Zamarin

Assistant Attending Physician

Alexander Lesokhin, MD
Alexander Lesokhin

Assistant Member

Nezar Mehanna
Nezar Mehanna

Research Technician

Michael Postow, MD
Michael Postow

Assistant Attending Physician

Danny Khalil

Medical Oncologist

Bianca Santomasso

Neuro-Oncologist

Allison Betof, MD, PhD
Allison Betof

Medical Oncologist

Arnab Ghosh, MBBS, PhD
Arnab Ghosh

Hematologic Oncologist

Andrew Chow

Medical Oncology Fellow

Bharat Burman
Bharat Burman

Medical Oncology Fellow

Sara Chekalil
Sara Chekalil
Anis Gasmi
Anis Gasmi

Graduate Research Assistant

Mariam George
Mariam George

Research Fellow

Ricardo Gomez
Ricardo Gomez

Research Technician

Linda Hamadene
Linda Hamadene

Senior Research Technician

Lukas Kraehenbuehl
Lukas Kraehenbuehl

Research Associate

Rachana Maniyar
Rachana Maniyar

Research Fellow

Raven Rose
Raven Rose

Project Coordinator

Divya Venkatesh
Divya Venkatesh

Research Fellow

Svena Verma
Svena Verma

Graduate Student

Hong Zhong
Hong Zhong

Senior Research Technician

Lab Alumni
Stephanie Terzulli

Immunotherapy Program Manager

David A. Schaer
David A. Schaer

Senior Research Scientist

Luis Felipe Campesato, PhD
Luis Felipe Campesato

Research Associate

Rikke B. Holmgaard

Research Fellow

Yuka Maeda

Research Fellow

Judith Murphy
Judith Murphy

Graduate Student

Nicole Malandro
Nicole Malandro

Graduate Student

Nouraiz Falik
Nouraiz Falik

Research Technician

Feng Zhao

Research Technician

Yanyun Li
Yanyun Li

Senior Research Assistant

Czrina Anne Cortez
Czrina Anne Cortez

Research Technician

Yonina Bykov
Yonina Bykov

Research Technician

Ceyhan Elipenahli
Ceyhan Elipenahli

Research Technician

Billel Gasmi
Billel Gasmi

Research Technician

Lauren Boucher

Research Technician

Andre P. Burey

Research Technician

Margaret K. Callahan, MD, PhD
Margaret K. Callahan

Assistant Attending, Department of Medicine

Tamar Plitt
Tamar Plitt

Research Technician

Kyle S. Draleau
Kyle S. Draleau

Research Technician

Claire   Friedman, MD
Claire Friedman

Medical Oncologist

Humilidad Gallardo

Research Laboratory Manager

Polly D. Gregor

Assistant Member

Robert Jenq

Research Fellow

Shigehisa Kitano

Visiting Investigator

Jeanie Melson

Administrative Assistant

Areej Assaf
Areej Assaf

Fulbright Scholar

Zhenyu Mu

Research Assistant

Kelly Piersanti

Research Technician

Rosemarie Ramsawak

Senior Research Technician

Teresa Rasalan

Research Assistant

Sapna Tandon

Senior Research Technician

Shachi Vyas

Senior Research Technician

Leila Sellam
Leila Sellam

Graduate Research Assistant

Jonathan Boiarsky
Jonathan Boiarsky
Olivier DeHenau

Research Fellow

Mohamed Amine Feliachi, Research Technician
Mohamed Amine Feliachi

Research Technician

Kelly Fitzgerald
Kelly Fitzgerald

Medical Oncology Fellow

Rachel Giese

Research Fellow

Stephane Pourpe

Research Assistant

David Redmond, PhD
David Redmond

Bioinformatics Engineer IV

Jacob Ricca, Research Technician
Jacob Ricca

Research Technician

Fadi Samaan
Fadi Samaan

Research Technician

David Schroder
David Schroder

Visiting Investigator

Yasin Senbabaoglu
Yasin Senbabaoglu
Nathan Suek
Nathan Suek

Research Technician

Tyler Walther

Research Technician

Lab Affiliations

Achievements

  • The use of immunomodulatory antibodies, specifically antibodies which interfere with the CTLA-4 co-inhibitory pathway has been studied in over a dozen clinical trials. Dr. Wolchok led a phase III study of ipilimumab plus dacarbazine in patients with previously untreated metastatic melanoma. Overall survival was significantly longer in the group receiving ipilimumab plus dacarbazine than in the group receiving dacarbazine plus placebo (Wolchok et al, NEJM 30;364(26):2517-26, 2011)

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Disclosures

Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Jedd D. Wolchok discloses the following relationships and financial interests:

  • Amgen
    Provision of Services (uncompensated)
  • Apricity Health
    Ownership / Equity Interests; Provision of Services
  • Arsenal IO Canada Parent, Inc.
    Ownership / Equity Interests; Provision of Services
  • Ascentage Pharma
    Ownership / Equity Interests; Provision of Services
  • Astellas
    Provision of Services (uncompensated)
  • AstraZeneca
    Provision of Services (uncompensated)
  • BeiGene, Ltd.
    Ownership / Equity Interests; Provision of Services
  • Bicara Therapeutics, Inc.
    Provision of Services
  • Boehringer Ingelheim
    Provision of Services (uncompensated)
  • Bristol-Myers Squibb
    Provision of Services
  • Chugai Pharmaceuticals
    Provision of Services (uncompensated)
  • Daiichi Sankyo
    Provision of Services
  • Dragonfly Therapeutics, Inc.
    Provision of Services (uncompensated)
  • Georgiamune, LLC
    Provision of Services (uncompensated)
  • Idera Pharmaceuticals, Inc.
    Provision of Services (uncompensated)
  • Imvaq Therapeutics
    Intellectual Property Rights; Ownership / Equity Interests; Provision of Services
  • Journal of Experimental Medicine
    Provision of Services
  • Linnaeus Therapeutics
    Ownership / Equity Interests
  • Maverick Therapeutics, Inc.
    Provision of Services
  • Merck & Co Inc.
    Intellectual Property Rights; Provision of Services (uncompensated)
  • Merial Limited
    Intellectual Property Rights
  • PsiOxus Therapeutics Ltd
    Provision of Services (uncompensated)
  • Recepta Biopharma S.A.
    Provision of Services (uncompensated)
  • Sellas Life Science Group
    Provision of Services
  • Surface Oncology
    Provision of Services
  • Tizona Therapeutics
    Ownership / Equity Interests; Provision of Services
  • Trieza Pharmaceuticals, Inc.
    Ownership / Equity Interests
  • Trishula Therapeutics, Inc.
    Provision of Services
  • Werewolf Therapeutics, Inc.
    Provision of Services

The information published here is for a specific annual disclosure period. There may be differences between information on this and other public sites as a result of different reporting periods and/or the various ways relationships and financial interests are categorized by organizations that publish such data.


This page and data include information for a specific MSK annual disclosure period (January 1, 2020 through disclosure submission in spring 2021). This data reflects interests that may or may not still exist. This data is updated annually.

Learn more about MSK’s COI policies here. For questions regarding MSK’s COI-related policies and procedures, email MSK’s Compliance Office at ecoi@mskcc.org.


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