Human Oncology & Pathogenesis Program

The Jedd Wolchok Lab

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Research

Pictured: Jedd Wolchok
Jedd D. Wolchok, MD, PhD, FASCO
Chief, Immuno-Oncology Service, Human Oncology and Pathogenesis Program

Professor

The overall goals of my laboratory efforts are to develop and implement new ways to use the immune system to treat cancer.

Some of our ongoing projects include:

  • Investigation of the GITR pathway as it relates to regulatory and effector T cells.
  • Use of OX40 agonists alone and in combination with chemotherapy.
  • Exploration of the role of myeloid derived suppressor cells in tumor immunity.
  • Studying of the mechanisms underlying coordinated regulation of myeloid cells and IDO in the tumor environment and their therapeutic relevance.
  • Role of CD47 in T cell signaling.
  • Developing optimal cancer vaccine strategies in pre-clinical mouse models.
  • Role of exercise in immune checkpoint blockade.

We are also closely aligned with the Ludwig Center for Cancer Immunity and work closely with that group to monitor immune responses in patients receiving experimental immunotherapy treatments.

The Jedd Wolchok Lab

Publications

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People

Pictured: Jedd Wolchok

Jedd D. Wolchok, MD, PhD, FASCO

Chief, Immuno-Oncology Service, Human Oncology and Pathogenesis Program

Professor

  • Physician-scientist Jedd Wolchok investigates novel approaches for cancer immunotherapy and mechanisms of tumor cell–immune cell interactions. He has been at the forefront of cancer immunotherapy, as an active clinician scientist exploring innovative immunotherapeutic strategies in laboratory models and as a principal investigator in numerous pivotal clinical trials.
  • Princeton University, Princeton, NJ BA
  • New York University, New York, NY MS
  • New York University, New York, NY PhD
  • New York University, New York, NY MD
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Physician profile

Members

Jedd D. Wolchok, MD, PhD, FASCO
Jedd D. Wolchok

Lab Head

Taha Merghoub, PhD
Taha Merghoub

Attending Biologist

Beatrice Yin, MA
Beatrice Yin

Research Lab Manager

Daniel Hirschhorn-Cymerman

Senior Research Scientist

Sadna Budhu, PhD
Sadna Budhu

Research Associate

Roberta Zappasodi, PhD
Roberta Zappasodi

PICI Bridge Scholar

Isabell Schulze
Isabell Schulze

Research Associate

Hyejin Choi, PhD
Hyejin Choi

Research Associate

Luis Felipe Campesato, PhD
Luis Felipe Campesato

Research Associate

Mathieu Gigoux

Research Fellow

Chien-Huan Weng

Research Fellow

Judith Michels, MD, PhD
Judith Michels

Research Fellow

Levi Mark Bala Mangarin, BS
Levi Mark Bala Mangarin

Bioinformatics Technician

Shakuntala Tiwari
Shakuntala Tiwari

Senior Research Assistant

Cailian Liu

Senior Research Assistant

Hong Zhong
Hong Zhong

Senior Research Technician

Xia Yang
Xia Yang

Senior Research Technician

Mohsen Abu-Akeel

Research Technician

Nouraiz Falik
Nouraiz Falik

Research Technician

Aliya Holland
Aliya Holland

Research Technician

Sara  Schad
Sara Schad

PhD Graduate Student

Lauren Dong
Lauren Dong

PhD Graduate Student

Dmitriy Zamarin, MD, PhD
Dmitriy Zamarin

Assistant Attending Physician

Yonina Bykov
Yonina Bykov

Research Technician

Alexander Lesokhin, MD
Alexander Lesokhin

Assistant Member

Nezar Mehanna
Nezar Mehanna

Research Technician

Michael Postow, MD
Michael Postow

Assistant Attending Physician

Margaret K. Callahan, MD, PhD
Margaret K. Callahan

Assistant Attending, Department of Medicine

Danny Khalil

Medical Oncologist

Bianca Santomasso

Neuro-Oncologist

Allison Betof, MD, PhD
Allison Betof

Medical Oncologist

Arnab Ghosh, MBBS, PhD
Arnab Ghosh

Hematologic Oncologist

Andrew Chow

Medical Oncology Fellow

Bharat Burman
Bharat Burman

Medical Oncology Fellow

Kelly Fitzgerald
Kelly Fitzgerald

Medical Oncology Fellow

Lukas Kraehenbuehl
Lukas Kraehenbuehl

Research Associate

Rachana Maniyar
Rachana Maniyar

Research Fellow

Raven Rose
Raven Rose

Project Coordinator

Fadi Samaan
Fadi Samaan

Research Technician

David Schroder
David Schroder

Visiting Investigator

Svena Verma
Svena Verma

Graduate Student

Lab Alumni
Stephanie Terzulli

Immunotherapy Program Manager

David A. Schaer
David A. Schaer

Senior Research Scientist

Rikke B. Holmgaard

Research Fellow

Yuka Maeda

Research Fellow

Judith Murphy
Judith Murphy

Graduate Student

Nicole Malandro
Nicole Malandro

Graduate Student

Feng Zhao

Research Technician

Yanyun Li
Yanyun Li

Senior Research Assistant

Czrina Anne Cortez
Czrina Anne Cortez

Research Technician

Ceyhan Elipenahli
Ceyhan Elipenahli

Research Technician

Billel Gasmi
Billel Gasmi

Research Technician

Lauren Boucher

Research Technician

Andre P. Burey

Research Technician

Tamar Plitt
Tamar Plitt

Research Technician

Kyle S. Draleau
Kyle S. Draleau

Research Technician

Claire   Friedman, MD
Claire Friedman

Medical Oncologist

Humilidad Gallardo

Research Laboratory Manager

Polly D. Gregor

Assistant Member

Robert Jenq

Research Fellow

Shigehisa Kitano

Visiting Investigator

Jeanie Melson

Administrative Assistant

Areej Assaf
Areej Assaf

Fulbright Scholar

Zhenyu Mu

Research Assistant

Kelly Piersanti

Research Technician

Rosemarie Ramsawak

Senior Research Technician

Teresa Rasalan

Research Assistant

Sapna Tandon

Senior Research Technician

Shachi Vyas

Senior Research Technician

Leila Sellam
Leila Sellam

Graduate Research Assistant

Jonathan Boiarsky
Jonathan Boiarsky
Olivier DeHenau

Research Fellow

Mohamed Amine Feliachi, Research Technician
Mohamed Amine Feliachi

Research Technician

Rachel Giese

Research Fellow

Stephane Pourpe

Research Assistant

David Redmond, PhD
David Redmond

Bioinformatics Engineer IV

Jacob Ricca, Research Technician
Jacob Ricca

Research Technician

Yasin Senbabaoglu
Yasin Senbabaoglu
Nathan Suek
Nathan Suek

Research Technician

Tyler Walther

Research Technician

Lab Affilations

Achievements

  • The use of immunomodulatory antibodies, specifically antibodies which interfere with the CTLA-4 co-inhibitory pathway has been studied in over a dozen clinical trials. Dr. Wolchok led a phase III study of ipilimumab plus dacarbazine in patients with previously untreated metastatic melanoma. Overall survival was significantly longer in the group receiving ipilimumab plus dacarbazine than in the group receiving dacarbazine plus placebo (Wolchok et al, NEJM 30;364(26):2517-26, 2011)

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