The overall goals of my laboratory efforts are to develop and implement new ways to use the immune system to treat cancer.
Some of our ongoing projects include:
- Investigation of the GITR pathway as it relates to regulatory and effector T cells.
- Use of OX40 agonists alone and in combination with chemotherapy.
- Exploration of the role of myeloid derived suppressor cells in tumor immunity.
- Studying of the mechanisms underlying coordinated regulation of myeloid cells and IDO in the tumor environment and their therapeutic relevance.
- Role of CD47 in T cell signaling.
- Developing optimal cancer vaccine strategies in pre-clinical mouse models.
- Role of exercise in immune checkpoint blockade.
We are also closely aligned with the Ludwig Center for Cancer Immunity and work closely with that group to monitor immune responses in patients receiving experimental immunotherapy treatments.
Jedd D. Wolchok, MD, PhD, FASCO
Lloyd J. Old/Virginia and Daniel K. Ludwig Chair in Clinical Investigation; Chief, Melanoma and Immunotherapeutics Service; Director, Parker Institute for Cancer Immunotherapy at MSK
Professor
Research Focus
Physician-scientist Jedd Wolchok investigates novel approaches for cancer immunotherapy and mechanisms of tumor cell–immune cell interactions. He has been at the forefront of cancer immunotherapy, as an active clinician scientist exploring innovative immunotherapeutic strategies in laboratory models and as a principal investigator in numerous pivotal clinical trials.Education
- Princeton University, Princeton, NJ BA
- New York University, New York, NY MS
- New York University, New York, NY PhD
- New York University, New York, NY MD
- Clinical Office 646-888-5178
- Lab Phone: 646-888-2585 (Laboratory Office)
Lab Members
Lab Head
Attending Biologist
Research Lab Manager
Senior Research Scientist
Research Associate
PICI Bridge Scholar
Research Associate
Research Associate
Research Associate
Research Fellow
Research Fellow
Research Fellow
Bioinformatics Technician
Senior Research Assistant
Senior Research Assistant
Senior Research Technician
Senior Research Technician
Research Technician
Research Technician
Research Technician
PhD Graduate Student
PhD Graduate Student
Assistant Attending Physician
Research Technician
Assistant Member
Research Technician
Assistant Attending Physician
Assistant Attending, Department of Medicine
Medical Oncologist
Medical Oncologist
Neuro-Oncologist
Medical Oncologist
Hematologic Oncologist
Medical Oncology Fellow
- Robert C, Thomas L, Bondarenko I, O’Day S, M DJ, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, Davidson N, Richards J, Maio M, Hauschild A, Miller WH, Jr., Gascon P, Lotem M, Harmankaya K, Ibrahim R, Francis S, Chen TT, Humphrey R, Hoos A, Wolchok JD. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364(26):2517-26
- Wolchok JD, Hoos A, O’Day S, Weber JS, Hamid O, Lebbe C, Maio M, Binder M, Bohnsack O, Nichol G, Humphrey R, Hodi FS. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res. 2009;15(23):7412-20.
- The use of immunomodulatory antibodies, specifically antibodies which interfere with the CTLA-4 co-inhibitory pathway has been studied in over a dozen clinical trials. Dr. Wolchok led a phase III study of ipilimumab plus dacarbazine in patients with previously untreated metastatic melanoma. Overall survival was significantly longer in the group receiving ipilimumab plus dacarbazine than in the group receiving dacarbazine plus placebo (Wolchok et al, NEJM 30;364(26):2517-26, 2011)
