Project description
Commensal and pathogenic microorganisms in the human gut (collectively the microbiome), are important regulators of the host immune response. Hematopoietic cell transplantation (HCT), a potentially curative intervention in hematologic malignancies, and other cellular therapies induce large perturbations in the microbiome as well as host immune system.
My goal is to understand how interactions between the microbiome and recovering immune system after HCT influence clinical outcomes such as disease relapse, graft-versus-host disease (GVHD), and infectious complications. I am interested in integrating multi-omics data assays of genetics, transcription, and metabolism to generate models describing the dynamics and kinetics of the interactions between (and within) the microbiome, tumor, and host.
Future directions will involve seeing if manipulation of easily modifiable interventions such as diet, medications, and probiotic therapy can influence these interactions to promote favorable clinical outcomes.
Awards
- John Mendelsohn Housestaff Teaching Award, MSKCC, 2021
Education
- Memorial Sloan Kettering Cancer Center Hematology/Oncology Fellowship, present
- Johns Hopkins Hospital, Osler Medical Residency (Internal Medicine), 2020
- Weill Cornell Medical College, M.D. 2017
- Princeton University, A.B. 2011