Link to Finley Lab publications
Selected Publications
A non-canonical tricarboxylic acid cycle underlies cellular identity.
Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. Nature. 2022 Mar;603(7901):477-481. doi: 10.1038/s41586-022-04475-w. Epub 2022 Mar 9. PMID: 35264789; PMCID: PMC8934290.
Extracellular serine controls epidermal stem cell fate and tumour initiation.
Baksh SC, Todorova PK, Gur-Cohen S, Hurwitz B, Ge Y, Novak JSS, Tierney MT, Dela Cruz-Racelis J, Fuchs E#, Finley LWS#. Nat Cell Biol. 2020 Jul;22(7):779-790. doi: 10.1038/s41556-020-0525-9. Epub 2020 May 25. Erratum in: Nat Cell Biol. 2020 Nov;22(11):1396. PMID: 32451440; PMCID: PMC7343604. (#co-corresponding author)
α-Ketoglutarate links p53 to cell fate during tumour suppression.
Morris JP 4th*, Yashinskie JJ*, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, Sánchez-Rivera FJ, Leach SD, Carmona-Fontaine C, Thompson CB, Finley LWS#, Lowe SW#. Nature. 2019 Sep;573(7775):595-599. doi: 10.1038/s41586-019-1577-5. Epub 2019 Sep 18. PMID: 31534224. (*co-first, #co-corresponding)
Glutamine independence is a selectable feature of pluripotent stem cells.
Vardhana SA, Arnold PK, Rosen BP, Chen Y, Carey BW, Huangfu D, Fontaine CC, Thompson CB, Finley LWS. Nat Metab. 2019 Jul;1(7):676-687. doi: 10.1038/s42255-019-0082-3. Epub 2019 Jul 8. PMID: 31511848
Pluripotency transcription factors and Tet1/2 maintain Brd4-independent stem cell identity.
Finley LWS*, Vardhana SA*, Carey BW*, Alonso-Curbelo D, Koche R, Chen Y, Wen D, King B, Radler MR, Rafii S, Lowe SW, Allis CD, Thompson CB. Nat Cell Biol. 2018 May;20(5):565-574. doi: 10.1038/s41556-018-0086-3. Epub 2018 Apr 16. PMID: 29662175 (* equal contribution)
Adrenergic nerves activate an angio-metabolic switch in prostate cancer.
Zahalka AH, Arnal-Estapé A, Maryanovich M, Nakahara F, Cruz CD, Finley LWS, Frenette PS. Science. 2017 Oct 20;358(6361):321-326. doi: 10.1126/science.aah5072. PMID: 29051371
PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2.
German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG Jr, Haigis MC. Mol Cell. 2016 Sep 15;63(6):1006-20. doi: 10.1016/j.molcel.2016.08.014. PMID: 27635760
Hypoxia Induces Production of L-2-Hydroxyglutarate.
Intlekofer AM, Dematteo RG, Venneti S, Finley LW, Lu C, Judkins AR, Rustenburg AS, Grinaway PB, Chodera JD, Cross JR, Thompson CB. Cell Metab. 2015 Aug 4;22(2):304-11. doi: 10.1016/j.cmet.2015.06.023. Epub 2015 Jul 23. PMID: 26212717
Intracellular α-ketoglutarate maintains the pluripotency of embryonic stem cells.
Carey BW*, Finley LW*, Cross JR, Allis CD, Thompson CB. Nature. 2015 Feb 19;518(7539):413-6. doi: 10.1038/nature13981. Epub 2014 Dec 10. PMID: 25487152. (*equal contribution)
Selected Review Articles
Regulation and function of the mammalian tricarboxylic acid cycle.
Arnold PK, Finley LWS. J Biol Chem. 2022 Dec 26:102838. doi: 10.1016/j.jbc.2022.102838. Epub ahead of print. PMID: 36581208.
Metabolic determinants of tumour initiation.
Brunner JS, Finley LWS. Nat Rev Endocrinol. 2022 Nov 29. doi: 10.1038/s41574-022-00773-5. Epub ahead of print. PMID: 36446897.
SnapShot: Cancer metabolism.
Brunner JS, Finley LWS. Mol Cell. 2021 Sep 16;81(18):3878-3878.e1. doi: 10.1016/j.molcel.2021.06.021. PMID: 34547243.
Metabolic Coordination of Cell Fate by α-Ketoglutarate-Dependent Dioxygenases.
Baksh SC, Finley LWS. Trends Cell Biol. 2021 Jan;31(1):24-36. doi: 10.1016/j.tcb.2020.09.010. Epub 2020 Oct 19. PMID: 33092942; PMCID: PMC7748998.
Metabolic signatures of cancer cells and stem cells.
Intlekofer AM, Finley LWS. Nat Metab. 2019 Feb;1(2):177-188. doi: 10.1038/s42255-019-0032-0. Epub 2019 Feb 11. PMID: 31245788