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30 News Items found
Nadeem Riaz (left) and Jorge Reis-Filho (right)
For People with Certain BRCA Mutations, Activating the Immune System Could Be Promising Treatment

Human data and results from mouse experiments suggest that people with BRCA2 mutations may respond well to immunotherapy drugs.
In the Lab
An illustration of sugar being sprinkled on a cancer cell.
Just Add Sugar: How a Protein’s Small Change Leads to Big Trouble for Cells

A study from investigators in the Sloan Kettering Institute uncovers the details of how a key protein called GRP94 becomes disrupted, leading to cancer and other diseases.
In the Lab
An illustration of a samurai riding a horse along a strand of RNA. The samurai’s sword is changing the letter A to the letter I.
Novel Tool Enables Study of Rare Acute Myeloid Leukemia Stem Cells

MSK investigators have used a lab tool originally developed to study fly nerve cells to uncover new findings about acute myeloid leukemia.
In the Lab
Physician-scientist Piro Lito
Why KRAS Inhibitors for Lung Cancer Stop Working (and What Can Be Done about It)

Recently developed targeted drugs used to treat lung cancer are only partially effective. Scientists now know why.
Finding
An illustration of sugar pouring onto NRF2
Sugar Directly Controls a Cancer-Causing Protein, Scientists Find

The discovery suggests a potential new treatment approach for certain cancers.
Finding
Computational biologist Barry Taylor
Whether a BRCA Mutation Leads to Cancer Depends on Context, Study Finds

Sometimes a BRCA mutation is just along for the ride, rather than driving a tumor’s development.
In the Lab
An illustration of a samurai and a crab.
Ro Versus Musashi: How One Molecule Can Turn Cancer Cells Back to Normal

Researchers identify a compound that appears to eliminate tumor cells in a dish and in mice.
Feature
Model of TGF-beta molecule
An Old Protein Gets a New Look: Researchers Target TGF-ß to Make Immunotherapy More Effective

Drugs that block the action of TGF-ß may make checkpoint inhibitors more effective.
In the Lab
Enhanced MRI of a glioblastoma
Starving Cancer Stem Cells Could Be the Trick to Treating Glioblastoma, Study Finds

MSK researchers have identified a compound that kills glioblastoma cells using a mechanism that’s completely different from earlier treatments.
Finding
Side-by-side pictures of tissues from a responder and a non-responder to targeted therapy for kidney cancer
For Kidney Cancer, the Tumor’s Environment May Be Key to Optimizing Treatment

One size does not fit all when it comes to treating renal cell carcinoma.