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30 News Items found
Nadeem Riaz (left) and Jorge Reis-Filho (right)
For People with Certain BRCA Mutations, Activating the Immune System Could Be Promising Treatment

Human data and results from mouse experiments suggest that people with BRCA2 mutations may respond well to immunotherapy drugs.
In the Lab
MSK immunologist Ming Li.
MSK-led Studies Support the Concept of “Cancer Environment Immunotherapy”

Targeting the cancer environment, rather than the cancer itself, could be a new avenue for immunotherapy.
MSK physician-scientists Michael Glickman and Gil Redelman-Sidi
The ABCs of BCG: Oldest Approved Immunotherapy Gets New Explanation

BCG has been used to treat bladder cancer for more than 30 years. Scientists are still learning how it works.
In the Lab
Fluorescent image of CAR T cells in mouse liver fibrosis
A New Target for CAR T Cells: Senescence-Related Diseases

From atherosclerosis and diabetes to liver fibrosis and osteoarthritis, senescent cells are at the root of many debilitating diseases. Scientists increasingly have them in the crosshairs.
In the Lab
Bacteroides bacteria under the microscope
Research Uncovers Details about How Gut Microbes Influence the Immune System

Investigators have shown how gut microbes promote the formation of a type of immune cell called regulatory T cells.
In the Lab
cartoon of man hitting a snooze button
Drug That Hits CAR T Snooze Button Can Quiet a Cytokine Storm

An FDA-approved drug used to treat leukemia can serve as a temporary off switch for CAR T cells, MSK scientists have found.
In the News
an illustration of cancer metastasis
AACR 2019 Research Roundup: Nanosensors for Cancer, New Immunotherapy Targets, a Road Map of Metastasis, and CAR T Fratricide

Read our key takeaways from the second half of the American Association for Cancer Research’s 2019 annual meeting.
In the News
AACR 2019 Annual Meeting
AACR 2019 Research Roundup: Pancreatic Cancer Immunotherapy, Prostate Cancer Drug Resistance, Insight into Inherited Cancer Mutations

Read up on the latest developments in several important areas of cancer research emerging from the 2019 American Association for Cancer Research annual meeting.
Finding
Tumor mutation model
Tumor Mutational Burden Can Help Predict Response to Immunotherapy in Many Different Cancers

Investigators confirmed that people whose tumors have a high tumor mutational burden and were treated with immunotherapy lived longer.
In the Lab
electron micrograph of a natural killer cell
Drugs That Stall — But Don’t Kill — Cancer Cells Are an Untapped Resource, Study Suggests

A drug combination that halts tumor cell division can stir the immune system into taking action.