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195 News Items found
Human metastatic melanoma cells in a lymph node. ENPP1, a protein involved in immune evasion, is shown in green.
Taking the STING Out of Cancer: Discovery about How Cancer Cells Evade Immune Defenses Inspires New Treatment Approach

The research identifies a protein called ENPP1 as a potential drug target in the treatment of advanced cancers with chromosome instability.
Dana Pe'er, Chair of the Computational and Systems Biology Program at the Sloan Kettering Institute
Year in Review: Top 10 MSK Cancer Science Breakthroughs of 2020

Take a look back at some of the biggest cancer science stories from this past year.
Regulatory proteins (gold balls) bind to enhancer regions (light blue) and promoter regions (pink) of DNA to form clusters that enable transcription (purple).
Going the Distance: How DNA Enhancers Communicate with Their Target Genes

Scientists at the Sloan Kettering Institute are learning how far-flung regions of genes connect to start the process of making proteins.
Finding
Section of a lung cancer tumor in mice
A Never-Before-Seen Cell State May Explain Cancer’s Ability to Resist Drugs

Identified in mice, this unusual cell state emerges early during tumor evolution and gives tumors enormous malleability.
MSK physician-scientists Michael Glickman and Gil Redelman-Sidi
The ABCs of BCG: Oldest Approved Immunotherapy Gets New Explanation

BCG has been used to treat bladder cancer for more than 30 years. Scientists are still learning how it works.
In the Lab
An illustration of sugar being sprinkled on a cancer cell.
Just Add Sugar: How a Protein’s Small Change Leads to Big Trouble for Cells

A study from investigators in the Sloan Kettering Institute uncovers the details of how a key protein called GRP94 becomes disrupted, leading to cancer and other diseases.
In the Lab
Confocal microscopy image of a female fruit fly brain.
How Fruit Flies Know When They've Mated

Research from investigators at the Sloan Kettering Institute shows how a brain circuit controls mating behavior in fruit flies.
In the Lab
CT scan showing lymphoma in the abdomen between the liver and the gallbladder.
A Metabolic Enzyme Drives Lymphoma and Is a Potential Drug Target

New research from Sloan Kettering Institute investigators pinpoints altered cell metabolism as a cause of B cell lymphoma.
In the Lab
Fluorescent image of CAR T cells in mouse liver fibrosis
A New Target for CAR T Cells: Senescence-Related Diseases

From atherosclerosis and diabetes to liver fibrosis and osteoarthritis, senescent cells are at the root of many debilitating diseases. Scientists increasingly have them in the crosshairs.
In the Lab
X and Y chromosomes in mice
Breaking Up Is Hard to Do (Especially for Sex Chromosomes)

One’s big, one’s small. Somehow, they make it work.