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30 News Items found
In the Lab
electron micrograph of a natural killer cell
Drugs That Stall — But Don’t Kill — Cancer Cells Are an Untapped Resource, Study Suggests

A drug combination that halts tumor cell division can stir the immune system into taking action.
In the Lab
Blue cells containing small red and green dots on a black background
Scientists Pinpoint a New Cause of Resistance to EGFR-Targeting Drugs

Multiple copies of a gene called <em>YES1</em> appear to be responsible for certain precision drugs losing their effectiveness.
Feature
A barred Plymouth Rock hen
How a Chicken Helped Solve the Mystery of Cancer

When this feathered patient found her way into a New York laboratory in 1909, she changed the course of cancer science.
Science Byte
Cancer biologist and pediatric oncologist Alex Kentsis
Blocking Enzymes That Signal DNA Damage Could Be a Treatment Strategy for Childhood Cancers

A new strategy for treating pediatric cancers involves preventing cells from repairing their own DNA.
In the Lab
Left-handed and right-handed KRas molecules
Mirror-Image Chemistry Enables New Approach for Targeting an “Undruggable” Cancer-Causing Protein

MSK chemists are focusing on developing small-molecule drugs to target KRas, an important cancer protein.
In the Lab
A cell in the process of dividing
New Study Shows How Wayward Chromosomes Get Back on Track

MSK researchers are learning how cells are able to recognize and correct errors that occur during cell division.
In the Lab
Organoid cell structures fluorescing in blue, green, and purple.
Manipulating a Single Gene Turns Colorectal Cancer Cells Back to Normal

For the first time, scientists have shown that the gene APC, which is mutated in the vast majority of colorectal cancers, might be a promising target for future therapies.
In the Lab
Portrait of a live zebrafish with dark patterning around and above the eyes
Uncharted Waters: The Making of a New Cancer Drug

A team of scientists is combining sophisticated chemistry and experiments in zebrafish to develop a new cancer drug that shows early potential against melanoma and metastatic breast cancer.
In the Lab
Proximal tubule of the kidney.
Miniature Device Could Unlock the Promise of Some Kidney Cancer Drugs

Memorial Sloan Kettering scientists have engineered a tiny particle that could ferry drugs directly to the kidneys and prevent their uptake in other organs.
In the Clinic
Pictured: Charles Sawyers
The Evolution of a Lifesaving Drug: A Scientist Reflects

Physician-scientist Charles Sawyers played a pivotal role in the development of Gleevec, one of the first successful targeted drugs for cancer.