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Finding
Alex Kentsis in his lab
Research Uncovers the Genetic Causes of Aggressive Leukemia in Children

Researchers have found that the genetic changes that cause pediatric leukemia are different from those that lead to leukemia in adults.
In the Clinic
Image of a mobile phone with a strand of DNA
There’s an App for That: When the Meaning of a BRCA Mutation Isn’t Clear-Cut

A new project called the BRCA Exchange is sharing data about BRCA mutations and what they actually mean for cancer risk.
In the Clinic
MRI of brain and spinal fluid in green
Analyzing Spinal Fluid Could Guide Brain Tumor Diagnosis and Treatment

Cancer DNA taken from spinal fluid could serve as a liquid biopsy that provides information on brain tumor mutations.
Finding
Tumor mutation model
Tumor Mutational Burden Can Help Predict Response to Immunotherapy in Many Different Cancers

Investigators confirmed that people whose tumors have a high tumor mutational burden and were treated with immunotherapy lived longer.
Finding
Side-by-side pictures of tissues from a responder and a non-responder to targeted therapy for kidney cancer
For Kidney Cancer, the Tumor’s Environment May Be Key to Optimizing Treatment

One size does not fit all when it comes to treating renal cell carcinoma.
Roundup
2018
Top 10 Stories of 2018, Cancer Research Edition

Take a look back at some of the year’s biggest news in cancer research.
In the Lab
Image of dividing breast cancer cells taken with electron microscope.
Researchers Identify Why Women May Develop Resistance to a New Class of Breast Cancer Drugs

Clues emerge about why promising new breast cancer drugs sometimes don’t work — and what might be done about it.
Feature
an illustration of a cigarette burning and smoke entering lungs
How Do Cigarettes Cause Cancer?

Everyone knows that cigarettes cause cancer. But what do we know about how they do it?
Roundup
ASH meeting signage
Advances in Myeloma, Lymphoma, and Bone Marrow Transplant Announced at the 2018 ASH Meeting

Learn more about the work of MSK researchers being presented at the 2018 meeting of the American Society of Hematology.
In the Clinic
A tube of blood superimposed on a lung and a DNA helix
Liquid Biopsy Is Effective at Guiding Treatment of Lung Cancer, Study Finds

The initial results of an ongoing study show that a liquid biopsy has advantages over a tissue biopsy for people with lung cancer.