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12 News Items found

Science Byte

Blocking Enzymes That Signal DNA Damage Could Be a Treatment Strategy for Childhood Cancers

A new strategy for treating pediatric cancers involves preventing cells from repairing their own DNA.

Graphic of shattered, red, DNA double-helix

In the Clinic

Genetic ‘Scars’ Provide Clues for Tailoring Cancer Treatment

For the first time, scientists have determined the extent of DNA repair deficiencies across cancer types. Learn what it means for patients.

Image of DNA helix with sequence in the background

Science Byte

Lifeguard on Duty: Looking at DNA Repair under a Microscope

Learn about what DNA repair looks like under a microscope.

Blue cells containing small red dots on a green and black background

in the Lab

Jumping Genes and the Dark Genome: MSK Researchers Gain New Insight into Childhood Cancers

Researchers have discovered a genetic mechanism that may trigger most childhood cancers.

Cartoon illustration of DNA double-helix segment (with arms and legs) “jumping” to from one part of the double-helix to another.

In the Lab

New Study Shows How Wayward Chromosomes Get Back on Track

MSK researchers are learning how cells are able to recognize and correct errors that occur during cell division.

A cell in the process of dividing

Feature

Understanding the DNA-Damage “First Responders”: John Petrini at Work

Scientists know that cancer can result from mistakes in DNA repair. But understanding what controls the repair process itself has been a hard nut to crack.

Molecular biologist John Petrini of the Sloan Kettering Institute.

Science Byte

A Clean Break: Scientists Make Surprising Discoveries about DNA Repair

A study reveals unexpected insights into how cells prepare broken DNA strands to be rejoined, preventing mutations that can cause cancer.

Illustration of DNA with green wrench making adjustments to a nut on the double helix.

Announcement

Expanding the Impact of Precision Medicine to Fuel Discoveries

MSK’s Functional Genomics Initiative will enable basic scientists to take full advantage of the massive amount of data produced by tumor sequencing.

Christina Leslie and John Petrini

In the Lab

Disorderly DNA: Researchers Simulate a Common Cause of Lung Cancer

For the first time, Memorial Sloan Kettering scientists have created a mouse model that replicates a subtype of non-small cell lung cancer caused by a chromosomal rearrangement — a type of mutation that is common in cancers but thus far has been very difficult to study.

Cancer biologist Andrea Ventura

Snapshot

Not So Fast: Dividing Cells Use a “Speed Limit” to Avoid Genetic Mistakes

The discovery of a molecular process that slows down cell division could provide new understanding about how some cancers develop.

Pictured: Human cell nucleus