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18 News Items found

In the Clinic

Longest-Running CAR T Trial Shows Which Patients Benefit Most, Have Fewest Side Effects

For adults with chemotherapy-resistant leukemia, CAR T cell therapy can be a lifesaving treatment option. New results suggest how to make it safer.

Medical oncologist Jae Park

In the Lab

Why Do Immune Checkpoint Inhibitors Work for Only Some People with Cancer?

Learn about why checkpoint inhibitors, a class of immunotherapy drugs, 
is paying off — but only for some patients.

MSK physician­scientist Luis Diaz

In the Clinic

The Science Behind the FDA’s Approval of an Immunotherapy for Mismatch Repair–Deficient Cancers

A new paper from MSK physician-scientist Luis Diaz presents the evidence on which the FDA approved the immunotherapy drug pembrolizumab for cancers with a specific genetic abnormality.

MSK medical oncologist Luis Diaz, Jr.

In the Lab

Why Immune Cells Sometimes Fail to Fight Cancer (and What to Do about It)

By looking at how DNA is packaged in cells, scientists are teasing apart a long-standing conundrum about the immune response to cancer.

Q&A

New Approach Could Boost Immunotherapy for Breast Cancer

A protein on certain immune cells is a promising target for making immunotherapy more effective against breast cancer.

Illustration of immune cell opening as if on hinge and boxing glove coming out.

The Warburg Effect: What Turns T Cells On?

Scientists have uncovered a surprising link between metabolism and gene control in T cells.

  • Monday, November 7, 2016

Announcement

News from #AACR16: Targeted Therapy Breakthrough, Improved Survival in Melanoma, and Benefits of Gut Bugs

Long-awaited results of clinical trials testing targeted drugs and immunotherapy combinations were on offer at the annual American Association for Cancer Research (AACR) conference.

Dr. Joan Massagué, Sloan Kettering Institute Director received the Pezcoller Foundation-AACR International Award for Cancer Research and was named an AACR fellow at AACR16.

In the Lab

In the Fight against Cancer, the Immune System Can Be a Double-Edged Sword

The immune system is a powerful tool for fighting cancer — sometimes too powerful.

photo of Foxo1 protein stained in regulatory T cells

In the Clinic

Report Highlights Advances Made at MSK That Are Changing Patients’ Lives

An annual report from an influential cancer group highlights three MSK studies that have advanced cancer research.

In the Lab

New Findings Clarify How Immunotherapy Works — and Why, In Some People, It Doesn’t

In people with melanoma who respond to the drug ipilimumab, certain mutations make tumors more visible to the immune system.

Pictured: Jedd Wolchok, Alexandra Snyder Charen and Timothy Chan