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Finding

Whether a BRCA Mutation Leads to Cancer Depends on Context, Study Finds

By Matthew Tontonoz

Sometimes a BRCA mutation is just along for the ride, rather than driving a tumor’s development.

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Computational biologist Barry Taylor discusses findings of a new study about BRCA genes.

In the Lab

Researchers Unravel the Biology of a Distinct Prostate Cancer Subtype

By Matthew Tontonoz

Mutations in a gene called FOXA1 are responsible for a distinct class of prostate cancer tumors, MSK researchers have found.

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MSK cancer researchers Elizabeth Adams, Charles Sawyers, and Rohit Bose

Feature

An Old Protein Gets a New Look: Researchers Target TGF-ß to Make Immunotherapy More Effective

By Julie Grisham

Drugs that block the action of TGF-ß may make checkpoint inhibitors more effective.

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Model of TGF-beta molecule

Finding

Research Uncovers the Genetic Causes of Aggressive Leukemia in Children

By Julie Grisham

Researchers have found that the genetic changes that cause pediatric leukemia are different from those that lead to leukemia in adults.

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Alex Kentsis in his lab

In The Clinic

Analyzing Spinal Fluid Could Guide Brain Tumor Diagnosis and Treatment

By Jim Stallard

Cancer DNA taken from spinal fluid could serve as a liquid biopsy that provides information on brain tumor mutations.

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MRI of brain and spinal fluid in green

Roundup

Top 10 Stories of the Year, Cancer Research Edition

By Matthew Tontonoz

Take a look back at some of the year’s biggest news in cancer research.

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2018

In the Clinic

Liquid Biopsy Is Effective at Guiding Treatment of Lung Cancer, Study Finds

By Matthew Tontonoz

The initial results of an ongoing study show that a liquid biopsy has advantages over a tissue biopsy for people with lung cancer.

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A tube of blood superimposed on a lung and a DNA helix

In the Lab

Scientists Pinpoint a New Cause of Resistance to EGFR-Targeting Drugs

By Matthew Tontonoz

Multiple copies of a gene called YES1 appear to be responsible for certain precision drugs losing their effectiveness.

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Blue cells containing small red and green dots on a black background

Feature

How a Chicken Helped Solve the Mystery of Cancer

By Matthew Tontonoz

When this feathered patient found her way into a New York laboratory in 1909, she changed the course of cancer science.

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A barred Plymouth Rock hen

In the Clinic

Genetic ‘Scars’ Provide Clues for Tailoring Cancer Treatment

By Matthew Tontonoz

For the first time, scientists have determined the extent of DNA repair deficiencies across cancer types. Learn what it means for patients.

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Image of DNA helix with sequence in the background