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In the Lab

Scientists Rewrite the Textbook of Organ Development, One Cell at a Time

By Matthew Tontonoz

A large study that analyzed nearly 120,000 cells in a developing mouse embryo is full of surprises.

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In this fluorescent microscopy image of endoderm tissue from a mouse embryo, cell membranes are red, cell nuclei are blue, and extra-embryonic endoderm cells are green (they appear turquoise because blue and green are merged).

In the News

AACR 2019 Research Roundup: Nanosensors for Cancer, New Immunotherapy Targets, a Road Map of Metastasis, and CAR T Fratricide

By Matthew Tontonoz Jim Stallard

Read our key takeaways from the second half of the American Association for Cancer Research’s 2019 annual meeting.

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an illustration of cancer metastasis

In the Clinic

CAR Therapy for Solid Tumors Draws Attention at Annual Cancer Conference

By Matthew Tontonoz

Results from a clinical trial indicate that an experimental CAR therapy for mesothelioma is safe.

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Scientific Image

In the Lab

A Death Wish That Allows Worms to Thrive — and What It Tells Us About Cancer Biology

By Julie Grisham

Researchers discover that a curious type of cell death plays a role in normal development.

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Microscopic image of cancer cells and C. elegans cells undergoing entosis.

In The Lab

Starving Cancer Stem Cells Could Be the Trick to Treating Glioblastoma, Study Finds

By Julie Grisham Matthew Tontonoz

MSK researchers have identified a compound that kills glioblastoma cells using a mechanism that’s completely different from earlier treatments.

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Enhanced MRI of a glioblastoma

Finding

For Kidney Cancer, the Tumor’s Environment May Be Key to Optimizing Treatment

By Matthew Tontonoz

One size does not fit all when it comes to treating renal cell carcinoma.

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Side-by-side pictures of tissues from a responder and a non-responder to targeted therapy for kidney cancer

Roundup

Top 10 Stories of the Year, Cancer Research Edition

By Matthew Tontonoz

Take a look back at some of the year’s biggest news in cancer research.

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2018

In the Lab

MSK Scientists Fine-Tune CAR T Cells to Improve Their Performance

By Matthew Tontonoz

The updated versions can survive longer in the body while still packing a punch against cancer.

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Illustration of mechanical arms altering a cell

In the Lab

The Immune System Can Fight Cancer. So Why Doesn’t It?

By Matthew Tontonoz

New research from scientists at the Sloan Kettering Institute helps explain how growing tumors escape our immune defenses.

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a cabinet full of yellow rubber duckies and one blue one

In the Lab

Researchers Identify Why Women May Develop Resistance to a New Class of Breast Cancer Drugs

By Jim Stallard

Clues emerge about why promising new breast cancer drugs sometimes don’t work — and what might be done about it.

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Image of dividing breast cancer cells taken with electron microscope.