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In the Lab

Checkpoint Challenge: When Releasing Immune Cell Brakes Is Not Enough to Stop Cancer

By Matthew Tontonoz

Scientists have learned that cutting a T cell’s brakes can have unexpected consequences.

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Immune cells surrounding a cancer cell

In The Lab

Computational “Hive Mind” Helps Scientists Solve an Enzyme’s Cryptic Movements

By Matthew Tontonoz

The breakthrough gives an unprecedented look at the varied and shifting poses of a protein in action.

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Two clusters of colored blobs with a diagram in the middle

Feature

How Do Immune Cells Kill Their Prey?

By Matthew Tontonoz

When an immune cell faces a foe, it has more than chemical weapons at its disposal.

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An illustration of an immune cell killing a cancer cell, and a snake attacking a mouse

In The Lab

Scientists Home In On “Equation” for Muscle Cell Size

By Matthew Tontonoz

A new study in flies reveals a previously unknown type of cooperation at work in muscle cells.

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Mutlinucleated muscle cells from flies

Feature

Beyond Sugar: What Cancer Cells Need to Grow

By Matthew Tontonoz

While sugar gets most of the attention as a cancer fuel, other nutrients can be equally important.

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a cartoon of a cancer cell spooning glutamine from a jar

In the Lab

Scientists Rewrite the Textbook of Organ Development, One Cell at a Time

By Matthew Tontonoz

A large study that analyzed nearly 120,000 cells in a developing mouse embryo is full of surprises.

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In this fluorescent microscopy image of endoderm tissue from a mouse embryo, cell membranes are red, cell nuclei are blue, and extra-embryonic endoderm cells are green (they appear turquoise because blue and green are merged).

In the News

AACR 2019 Research Roundup: Nanosensors for Cancer, New Immunotherapy Targets, a Road Map of Metastasis, and CAR T Fratricide

By Matthew Tontonoz Jim Stallard

Read our key takeaways from the second half of the American Association for Cancer Research’s 2019 annual meeting.

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an illustration of cancer metastasis

In the Clinic

CAR Therapy for Solid Tumors Draws Attention at Annual Cancer Conference

By Matthew Tontonoz

Results from a clinical trial indicate that an experimental CAR therapy for mesothelioma is safe.

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Scientific Image

In the Lab

A Death Wish That Allows Worms to Thrive — and What It Tells Us About Cancer Biology

By Julie Grisham

Researchers discover that a curious type of cell death plays a role in normal development.

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Microscopic image of cancer cells and C. elegans cells undergoing entosis.

In The Lab

Starving Cancer Stem Cells Could Be the Trick to Treating Glioblastoma, Study Finds

By Julie Grisham Matthew Tontonoz

MSK researchers have identified a compound that kills glioblastoma cells using a mechanism that’s completely different from earlier treatments.

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Enhanced MRI of a glioblastoma