Recent News: Lab Research

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152 News Items found
Finding
Yonina Murciano-Goroff, Jenny Xue, Bob Li, Piro Lito, and Yulei Zhao.
MSK Researchers Are Learning Why Some Patients Develop Resistance to ‘Landmark’ Lung Cancer Drug

A paper from MSK researchers reports that resistance to sotorasib, a new targeted drug for lung cancer, can be caused by many different molecular changes.
In the Lab
Scientist Gabriela Chiosis in her lab
Experimental Drug Targets Misbehaving Proteins in Brain Cancer and Alzheimer’s Disease

Memorial Sloan Kettering researchers are studying how drugs that reverse malfunctioning proteins may treat disease.
Finding
Section of a lung cancer tumor in mice
A Never-Before-Seen Cell State May Explain Cancer’s Ability to Resist Drugs

Identified in mice, this unusual cell state emerges early during tumor evolution and gives tumors enormous malleability.
MSK physician-scientists Michael Glickman and Gil Redelman-Sidi
The ABCs of BCG: Oldest Approved Immunotherapy Gets New Explanation

BCG has been used to treat bladder cancer for more than 30 years. Scientists are still learning how it works.
In the Lab
An illustration of sugar being sprinkled on a cancer cell.
Just Add Sugar: How a Protein’s Small Change Leads to Big Trouble for Cells

A study from investigators in the Sloan Kettering Institute uncovers the details of how a key protein called GRP94 becomes disrupted, leading to cancer and other diseases.
In the Lab
Confocal microscopy image of a female fruit fly brain.
How Fruit Flies Know When They've Mated

Research from investigators at the Sloan Kettering Institute shows how a brain circuit controls mating behavior in fruit flies.
In the Lab
CT scan showing lymphoma in the abdomen between the liver and the gallbladder.
A Metabolic Enzyme Drives Lymphoma and Is a Potential Drug Target

New research from Sloan Kettering Institute investigators pinpoints altered cell metabolism as a cause of B cell lymphoma.
In the Lab
X and Y chromosomes in mice
Breaking Up Is Hard to Do (Especially for Sex Chromosomes)

One’s big, one’s small. Somehow, they make it work.
Feature
Two gloved hands opening a drawer in a laboratory.
Double Trouble: Researchers Find Many Cancers Carry Two Mutations in the Same Gene

Discovery reveals that the genetic causes of cancer may be more complicated than previously thought.
In Brief
A fluorescent image of cells undergoing differentiation in a mouse model.
Cancer Stem Cells’ Reliance on a Key Amino Acid Could Be an Exploitable Weakness

The discovery links metabolism to the way cancer stem cells form tumors.