Recent News: Cancer Genetics & Genomics

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56 News Items found

In the Clinic

Liquid Biopsy Is Effective at Guiding Treatment of Lung Cancer, Study Finds

By Matthew Tontonoz

The initial results of an ongoing study show that a liquid biopsy has advantages over a tissue biopsy for people with lung cancer.

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A tube of blood superimposed on a lung and a DNA helix

In the Lab

In a Twist, Scientists Find Cancer Drivers Hiding in RNA, Not DNA

By Matthew Tontonoz

New findings from researchers at the Sloan Kettering Institute suggest that cancer causes may be lurking in the molecule that bridges DNA and protein.

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Sloan Kettering Institute molecular biologist Christine Mayr

In the Lab

Scientists Identify Growth Signal for Metastatic Cancer "Seeds"

By Matthew Tontonoz

Targeting this signal with drugs might be one way to stop cancers from spreading.

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This image shows cancer cells (white) and pericytes (green) clinging to capillaries (red). The blue dots are nuclei.

In the Lab

With Help of CRISPR, Scientists Unravel the Cause of a Rare Liver Cancer

By Matthew Tontonoz

A team led by MSK molecular biologist Scott Lowe is making progress against fibrolamellar hepatocellular carcinoma.

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A microscopic view of genetically engineered mouse tumor and a human FL-HCC tumor

Science Byte

Blocking Enzymes That Signal DNA Damage Could Be a Treatment Strategy for Childhood Cancers

By Jim Stallard

A new strategy for treating pediatric cancers involves preventing cells from repairing their own DNA.

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Graphic of shattered, red, DNA double-helix

Finding

Making an IMPACT: MSK’s Gene-Sequencing Test Reveals New Findings about Hereditary Cancer Risk

By Julie Grisham

An analysis of germline DNA in people with advanced cancer finds that inherited mutations may be more common than expected in this group.

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Kenneth Offit and Vijai Joseph

In the Lab

When Loss Is a Gain: New Tumor Suppressor Gene Identified in Follicular Lymphoma

By Matthew Tontonoz

The reason certain patients with follicular lymphoma do worse than others may come down to a missing gene.

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A scientist looks at illustrations of chromosomes.

In the Clinic

The Science Behind the FDA’s Approval of an Immunotherapy for Mismatch Repair–Deficient Cancers

By Matthew Tontonoz

A new paper from MSK physician-scientist Luis Diaz presents the evidence on which the FDA approved the immunotherapy drug pembrolizumab for cancers with a specific genetic abnormality.

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MSK medical oncologist Luis Diaz, Jr.

Science Byte

Lifeguard on Duty: Looking at DNA Repair under a Microscope

By Gesa Junge

Learn about what DNA repair looks like under a microscope.

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Blue cells containing small red dots on a green and black background

in the Lab

Jumping Genes and the Dark Genome: MSK Researchers Gain New Insight into Childhood Cancers

By Jim Stallard

Researchers have discovered a genetic mechanism that may trigger most childhood cancers.

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Cartoon illustration of DNA double-helix segment (with arms and legs) “jumping” to from one part of the double-helix to another.