Recent News: Cancer Genetics & Genomics

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Finding

Research Uncovers the Genetic Causes of Aggressive Leukemia in Children

By Julie Grisham

Researchers have found that the genetic changes that cause pediatric leukemia are different from those that lead to leukemia in adults.

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Alex Kentsis in his lab

In The Clinic

There’s an App for That: When the Meaning of a BRCA Mutation Isn’t Clear-Cut

By Julie Grisham

A new project called the BRCA Exchange is sharing data about BRCA mutations and what they actually mean for cancer risk.

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Image of a mobile phone with a strand of DNA

In the Lab

Drugs That Stall — But Don’t Kill — Cancer Cells Are an Untapped Resource, Study Suggests

By Matthew Tontonoz

A drug combination that halts tumor cell division can stir the immune system into taking action.

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electron micrograph of a natural killer cell

In the Clinic

Liquid Biopsy Is Effective at Guiding Treatment of Lung Cancer, Study Finds

By Matthew Tontonoz

The initial results of an ongoing study show that a liquid biopsy has advantages over a tissue biopsy for people with lung cancer.

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A tube of blood superimposed on a lung and a DNA helix

In the Lab

In a Twist, Scientists Find Cancer Drivers Hiding in RNA, Not DNA

By Matthew Tontonoz

New findings from researchers at the Sloan Kettering Institute suggest that cancer causes may be lurking in the molecule that bridges DNA and protein.

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Sloan Kettering Institute molecular biologist Christine Mayr

In the Lab

Scientists Identify Growth Signal for Metastatic Cancer "Seeds"

By Matthew Tontonoz

Targeting this signal with drugs might be one way to stop cancers from spreading.

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This image shows cancer cells (white) and pericytes (green) clinging to capillaries (red). The blue dots are nuclei.

In the Lab

With Help of CRISPR, Scientists Unravel the Cause of a Rare Liver Cancer

By Matthew Tontonoz

A team led by MSK molecular biologist Scott Lowe is making progress against fibrolamellar hepatocellular carcinoma.

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A microscopic view of genetically engineered mouse tumor and a human FL-HCC tumor

Science Byte

Blocking Enzymes That Signal DNA Damage Could Be a Treatment Strategy for Childhood Cancers

By Jim Stallard

A new strategy for treating pediatric cancers involves preventing cells from repairing their own DNA.

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Graphic of shattered, red, DNA double-helix

Finding

Making an IMPACT: MSK’s Gene-Sequencing Test Reveals New Findings about Hereditary Cancer Risk

By Julie Grisham

An analysis of germline DNA in people with advanced cancer finds that inherited mutations may be more common than expected in this group.

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Kenneth Offit and Vijai Joseph

In the Lab

When Loss Is a Gain: New Tumor Suppressor Gene Identified in Follicular Lymphoma

By Matthew Tontonoz

The reason certain patients with follicular lymphoma do worse than others may come down to a missing gene.

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A scientist looks at illustrations of chromosomes.