Selected Publications

Here are our selected publications.

Li YM, Milne JC, Madison LL, Kolter R, Walsh CT. From peptide precursors to oxazole and thiazole-containing peptide antibiotics: microcin B17 synthase. Science. 1996;274:1188-1193.

Li YM, Xu M, Lai MT, Huang Q, Castro JL, DiMuzio-Mower J, Harrison T, Lellis C, Nadin A, Neduvelil JG, Register RB, Sardana MK, Shearman MS, Smith AL, Shi XP, Yin KC, Shafer JA, Gardell SJ. Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. Nature. 2000;405:689-694.

Li YM, Lai MT, Xu M, Huang Q, DiMuzio-Mower J, Sardana MK, Shi XP, Yin KC, Shafer JA, Gardell SJ. Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. Proc Natl Acad Sci USA. 2000;97:6138-6143.

Li YM. Gamma-Secretase: a catalyst of Alzheimer disease and signal transduction. Mol Interv. 2001;1:198-207.

Xu M, Lai MT, Huang Q, DiMuzio-Mower J, Castro JL, Harrison T, Nadin A, Neduvelil JG, Shearman MS, Shafer JA, Gardell SJ, Li YM. gamma-Secretase: characterization and implication for Alzheimer disease therapy. Neurobiol Aging. 2002;23:1023-1030.

Lai MT, Chen E, Crouthamel MC, DiMuzio-Mower J, Xu M, Huang Q, Price E, Register RB, Shi XP, Donoviel DB, Bernstein A, Hazuda D, Gardell SJ, Li YM. Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities. J Biol Chem. 2003;278:22475-22481.

Tarassishin L, Yin YI, Bassit B, Li YM. Processing of Notch and amyloid precursor protein by {gamma}-secretase is spatially distinct. Proc Natl Acad Sci USA. 2004;101:17050-17055.

Netzer WJ, Dou F, Cai D, Veach D, Jean S, Li Y, Bornmann WG, Clarkson B, Xu H, Greengard P. Gleevec inhibits beta-amyloid production but not Notch cleavage. Proc Natl Acad Sci USA. 2003;100:12444-12449.

Chun J, Yin YI, Yang G, Tarassishin L, Li YM. Stereoselective synthesis of photoreactive peptidomimetic gamma-secretase inhibitors. J Org Chem. 2004;69:7344-7347.

Cho YS, Carcache DA, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. J Am Chem Soc. 2004;126:14358-14359.

Yin YI, Bassit B, Zhu L, Wang C,and Li Y.M. gamma-secretase substrate concentration modulates the abeta 42/abeta40 ratio: Implications for Alzheimer's disease. J. Biol. Chem. 2007; 282:23639-44

Lei X, Ahn K, Zhu L, Ubarretxena-Belandia I and Li YM. Soluble Oligomers of the Intramembrane Serine Protease YqgP Are Catalytically Active in the Absence of Detergents. Biochemistry 2008;47:11920-9

Meng RD, Shelton CC, Li YM, Qin LX, Notterman D, Paty PB, Schwartz GK. Gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009;69:573-82

Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and Presenilin-1 Modulate the Dynamic Equilibrium of Presenilin-1 and Presenilin-2 gamma-Secretase Complexes. J.Biol.Chem. 2009; 284:2967-77

Yang G, Yin YI, Chun J, Shelton CC, Ouerfelli O, Li YM. Stereo-controlled synthesis of novel photoreactive gamma-secretase inhibitors. Bioorg Med Chem Lett. 2009;19(3):922-5

Placanica L,Zhu L and Li YM. Gender and Age Dependent gamma-Secretase Activity in Mouse Brain and its Implication in Sporadic Alzheimer Disease. PloS One 2009; 4(4):e5088

Shelton CC, Tian Y, Frattini MG, Li YM. An exo-cell assay for examining real-time gamma-secretase activity and inhibition. Mol Neurodegener. 2009;4:22

Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah D, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proc Natl Acad Sci USA 2009;

Lei X, Li YM. The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity. J. Mol. Biol. 2009;394;815-825

Tian Y, Bassit B, Chau D, Li YM. An APP inhibitory domain containing the Flemish mutation residue modulates gamma-secretase activity for Abeta production. Nat. Struct. Mol Biol. 2010; Feb; 17(2):151-8

Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 9;67(5):769-80.

Placanica L, Chien JW, Li YM. Characterization of an atypical gamma-secretase complex from hematopoietic origin. Biochemistry. 2010 Apr 6;49(13):2796-804.

Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010 Nov 1;24(21):2395-407.

Tian Y, Crump CJ, Li YM. Dual role of alpha-secretase cleavage in the regulation of gamma-secretase activity for amyloid production. J Biol Chem. 2010 Oct 15;285(42):32549-56.

1. Ahn K, Shelton CC, Tian Y, Zhang X, Gilchrist ML, Sisodia SS, Li Y-M. Activation and intrinsic γ-secretase activity of presenilin 1. Proc Natl Acad Sci U S A. 2010;107(50):21435-40.

Cover story and Commentary on Proc Natl Acad Sci U S A. 2010 Nov 29. PNAS 2010 Dec 14;107(50):236-7.

Editor’s Dozen by The Alzheimer Research Forum: 13 Top AD Trends in 2010.

Research News by The Alzheimer Research Forum: Sole Perp—PS1 Alone Reconstitutes γ-Secretase Activity.

Renzi F, Zhang X, Rice WJ, Torres-Arancivia C, Gomez-Llorente Y, Diaz R, Ahn K, Yu C, Li YM, Sisodia SS, Ubarretxena-Belandia I. Structure of gamma-secretase and its trimeric pre-activation intermediate by single-particle electron microscopy. J Biol Chem. 2011;286(24):21440-9.

Wu J, Petralia RS, Kurushima H, Patel H, Jung MY, Volk L, Chowdhury S, Shepherd JD, Dehoff M, Li Y, Kuhl D, Huganir RL, Price DL, Scannevin R, Troncoso JC, Wong PC, Worley PF. Arc/Arg3.1 Regulates an Endosomal Pathway Essential for Activity-Dependent beta-Amyloid Generation. Cell. 2011;147(3):615-28.

Li T, Li YM, Ahn K, Price DL, Sisodia SS, Wong PC. Increased Expression of PS1 Is Sufficient to Elevate the Level and Activity of gamma-Secretase In Vivo. PLoS One. 2011;6(11):e28179.

Crump CJ, Fish BA, Castro SV, Chau D-M, Gertsik N, Ahn K, Stiff C, Pozdnyakov N, Bales KR, Johnson DS, Li Y-M. Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1. ACS Chemical Neuroscience. 2011;2(12):705-10.

Crump CJ, Johnson DS, Li YM. Target of gamma-secretase modulators, presenilin marks the spot. EMBO J. 2011;30(23):4696-8.

Visit PubMed for full listing of Yueming Li journal articles

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