Selected Publications

Here is a list of the selected publications:

Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen W-L, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F, Melia TJ, Klionsky DJ. SNARE Proteins Are Required for Macroautophagy. Cell 2011 (146) 290-302.

Wang X, Wang J, and Jiang X. MdmX Protein Is Essential for Mdm2 Protein-Mediated p53 Polyubiquitination. J. Biol. Chem. 2011 (286) 23725-23734.

Ganley IG, Wong P-M, Gammoh N, Jiang X. Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest. Molecular Cell 2011 (42):731-743.

Gao Z, Gammoh N, Wong P, Erdjument-Bromage H, Tempst P, Jiang X. Processing of Autophagic Protein LC3 by the 20S Proteasome. Autophagy 2010 (6) 126-137.

Pan W, da Graca, LS, Shao Y, Yin Q, Wu H, Jiang X. PHAPI/pp32 Suppresses Tumorigenesis by Stimulating Apoptosis. J. Biol. Chem. 2009 (284) 6946-6954.

Ganley IG, Lam DH, Wang J, Ding X, Chen S, Jiang X. ULK1-ATG13-FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy. J. Biol. Chem. 2009 (284) 12297-12305.

Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen W-L, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F, Melia TJ, Klionsky DJ. SNARE Proteins Are Required for Macroautophagy. Cell 2011 (146) 290-302.

Wang X, Wang J, and Jiang X. MdmX Protein Is Essential for Mdm2 Protein-Mediated p53 Polyubiquitination. J. Biol. Chem. 2011 (286) 23725-23734.

Ganley IG, Wong P-M, Gammoh N, Jiang X. Distinct Autophagosomal-Lysosomal Fusion Mechanism Revealed by Thapsigargin-Induced Autophagy Arrest. Molecular Cell 2011 (42):731-743.

Gao Z, Gammoh N, Wong P, Erdjument-Bromage H, Tempst P, Jiang X. Processing of Autophagic Protein LC3 by the 20S Proteasome. Autophagy 2010 (6) 126-137.

Pan W, da Graca, LS, Shao Y, Yin Q, Wu H, Jiang X. PHAPI/pp32 Suppresses Tumorigenesis by Stimulating Apoptosis. J. Biol. Chem. 2009 (284) 6946-6954.

Ganley IG, Lam DH, Wang J, Ding X, Chen S, Jiang X. ULK1-ATG13-FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy. J. Biol. Chem. 2009 (284) 12297-12305.

Kim H-E, Jiang X, Du F, Wang X. PHAPI, CAS, and Hsp70 Promote Apoptosome Formation by Preventing Apaf-1 Aggregation and Enhancing Nucleotide Exchange on Apaf-1. Molecular Cell 2008 (30) 239-247.

Wang X, Jiang X. Posttranslational Regulation of PTEN. Oncogene 2008 (27) 5454-5463. Wang X, Trotman L, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. NEDD4-1 is a Proto-Oncogenic Ubiquitin Ligase for PTEN. Cell 2007 (128) 129-139.

Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Chi S, Kim H, Yang H, Pavletich NP, Carver BS, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Misteli T, Jiang X, Pandolfi PP. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 2007 (128) 141-156.

Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, Brodsky JL, Krystal GW, Chiosis G. Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nat. Chem. Biol. 2007 (3) 498-507.

Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Medicine 2007 (4) e294, 1655-1668.

Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li Y, Jiang X. A Dimeric Smac/Diablo Peptide Directly Relieves Caspase-3 Inhibition by XIAP: Dynamic and Cooperative Regulation of XIAP by Smac/Diablo. J. Biol. Chem. 2007 (282) 30718-30727.

Yin Q, Park HH, Chung JY, Lin SC, Lo YC, da Graca LS, Jiang X, Wu H. Caspase-9 holoenzyme is a specific and optimal pro-caspase-3 processing machine. Molecular Cell 2006 (22) 259-268.

Gao Z, Shao Y, Jiang X. Essential Roles of the Bcl-2 Family of Proteins in Caspase-2-Induced Apoptosis. J. Biol. Chem. 2005 (280) 38271-38275.

Ungerstedt JS , Sowa Y, Xu W-S, Shao Y, Perez G, Ngo L, Holmgren A, Jiang X, Marks PA. Role of Thioredoxin in the Response of Normal and Transformed Cells to Histone Deacetylase Inhibitors. Proc Natl Acad Sci U S A 2005 (102) 673-678.

Shao Y, Gao Z, Marks PA, Jiang X. Apoptotic and Autophagic Cell Death Induced by Histone Deacetylase Inhibitors. Proc Natl Acad Sci U S A 2004 (101) 18030-18035.

Jiang X, Wang X. Cytochrome c-Mediated Apoptosis. Ann. Rev. Biochem. 2004 (73) 87-106.

Jiang X, Kim H, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng S, Rosenberg S, Wang X. Distinctive Roles of PHAP Proteins and Prothymosin-a in a Death Regulatory Pathway. Science 2003 (299): 223-226.

Ganley IG, Lam DH, Wang J, Ding X, Chen S, Jiang X. ULK1-ATG13-FIP200 Complex Mediates mTOR Signaling and is Essential for Autophagy. J. Biol. Chem. 2009 (284) 12297-12305.

Pan W, da Graca LS, Shao Y, Yin Q, Wu H, Jiang X. PHAPI/pp32 Suppresses Tumorigenesis by Stimulating Apoptosis. J. Biol. Chem. 2009 (284) 6946-6954.

Kim H-E, Jiang X, Du F, Wang X. PHAPI, CAS, and Hsp70 Promote Apoptosome Formation by Preventing Apaf-1 Aggregation and Enhancing Nucleotide Exchange on Apaf-1. Molecular Cell 2008 (30) 239-247.

Wang X, Jiang X. Posttranslational Regulation of PTEN. Oncogene 2008 (27) 5454-5463.

Wang X, Trotman L, Koppie T, Alimonti A, Chen Z, Gao Z, Wang J, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Pandolfi PP, Jiang X. NEDD4-1 is a Proto-Oncogenic Ubiquitin Ligase for PTEN. Cell 2007 (128) 129-139.

Trotman LC, Wang X, Alimonti A, Chen Z, Teruya-Feldstein J, Chi S, Kim H, Yang H, Pavletich NP, Carver BS, Erdjument-Bromage H, Tempst P, Cordon-Cardo C, Misteli T, Jiang X, Pandolfi PP. Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 2007 (128) 141-156.

Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li Y, Jiang X. A Dimeric Smac/Diablo Peptide Directly Relieves Caspase-3 Inhibition by XIAP: Dynamic and Cooperative Regulation of XIAP by Smac/Diablo. J. Biol. Chem. 2007 (282) 30718-30727.

Gong Y, Somwar R, Politi K, Balak M, Chmielecki J, Jiang X, Pao W. Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas. PLoS Medicine 2007 (4) e294, 1655-1668.

Shao Y, Gao Z, Feldman T, Jiang X. Stimulation of ATG12-ATG5 conjugation by Ribonucleic Acid. Autophagy 2007 (3) 10-16.

Yin Q, Park HH, Chung JY, Lin SC, Lo YC, da Graca LS, Jiang X, Wu H. Caspase-9 holoenzyme is a specific and optimal pro-caspase-3 processing machine. Molecular Cell 2006 (22) 259-268.

Gao Z, Shao Y, Jiang X. Essential Roles of the Bcl-2 Family of Proteins in Caspase-2-Induced Apoptosis. J. Biol. Chem. 2005 (280) 38271-38275.

Marks PA, Jiang X. Histone Deacetylase Inhibitors in Programmed Cell Death and Cancer Therapy. Cell Cycle 2005 (4) 549-551.

Shao Y, Gao Z, Marks PA, Jiang X. Apoptotic and Autophagic Cell Death Induced by Histone Deacetylase Inhibitors. Proc Natl Acad Sci U S A 2004 (101) 18030-18035.

Jiang X, Wang X. Cytochrome c-Mediated Apoptosis. Ann. Rev. Biochem. 2004 (73) 87-106.

Jiang X, Kim H, Shu H, Zhao Y, Zhang H, Kofron J, Donnelly J, Burns D, Ng S, Rosenberg S, Wang X. Distinctive Roles of PHAP Proteins and Prothymosin-α in a Death Regulatory Pathway. Science (Research Article) 2003 (299): 223-226.

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