Justine D. Miller
Graduate Student - currently: Postdoctoral fellow with Sally Temple
My interests include reprogramming, disease modeling and cell therapy. More specifically, I am interested in studying the aging of hiPSC-derived differentiated cells for their application in disease modeling and cell therapy of later-onset disorders. Currently, differentiation protocols generate cells with an immature phenotype. In order to promote the adult phenotype, stress-inducing agents have been employed in vitro in an attempt to mimic aging. These methods, however, have proven to be inefficient and met with limited success. I would like to further dissect the aging process in multiple cell lineages using an inducible model system of Hutchinson-Gilford Progeria Syndrome, a premature aging disorder.