Selected Publications

Cheng E.H.-Y., Levine B., Boise L.H., Thompson C.B. and Hardwick J.M. Bax-independent inhibition of apoptosis by Bcl-xL. Nature 1995; 379:554-556.

Cheng E.H.-Y., Nicholas J., Bellows D.S., Hayward G.S., Guo H., Reitz M.S. and Hardwick J.M. A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpes virus 8, inhibits apoptosis but does not heterodimerize with BAX or BAK inhibits apoptosis. Proc Natl Acad Sci USA 1996; 94:690-694.

Cheng E.H.-Y., Kirsch D.G., Clem R.J., Ravi R., Kastan K.B., Bedi A., Ueno K. and Hardwick J. M. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science 1997; 278:1966-1968.

Clem R.J., Cheng E.H.-Y., Karp C.L., Kirsch D. G., Ueno K., Takahashi A., Kastan M.B., Griffin D.E., Earnshaw W.C., Veliuna M.A. and Hardwick J.M. Modulation of cell death by Bcl-xL through caspase interaction. Proc Natl Acad Sci USA 1998; 95:554-559.

Chau B.N., Cheng E.H.-Y., Kerr D.A. and Hardwick J.M. Aven, a novel inhibitor of caspase activation binds Bcl-xL and Apaf-1. Molecular Cell 2000; 6:31-40.

Wei M.C., Zong W.-X., Cheng E.H.-Y., Lindsten T., Panoutsakopoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B. and Korsmeyer S.J. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001; 292:727-730.

Cheng E.H.-Y., Wei M.C., Weiler S., Flavell R.A., Mak T.W., Lindsten T. and Korsmeyer S.J. BCL-2, Bcl-xL sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Molecular Cell 2001; 8:705-711.

Scorrano L., Oakes S.A., Opferman J.T., Cheng E.H.-Y., Sorcinelli M.D., Pozzan T. and Korsmeyer S.J. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science 2003; 300:135-139.

Cheng E.H.-Y., Sheiko T.V., Fisher J.K., Craigen W.J. and Korsmeyer S.J. VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis. Science 2003; 301:513-517.

Hsieh J. J.-D., Cheng E. H.-Y., Korsmeyer S. J. Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell 2003; 115:293-303.

Kim H., Rafiuddin-Shah M., Tu H.-C, Jeffers J., Zambetti G.P., Hsieh J. J.-D., Cheng E.H.-Y. Hierarchical Regulation of Mitochondrion-Dependent Apoptosis by BCL-2 subfamilies. Nature Cell Biology, 2006; 8:1348-1358.

Gavathiotis E., Suzuki M., Davis M.L., Pitter K., Bird G.H., Katz S.G., Tu H.C., Kim H., Cheng E.H.-Y., Tjandra N., Walensky L.D. BAX activation is initiated at a novel interaction site. Nature 2008; 455:1076-1081.

Tu H.-C., Ren D., Wang G., Chen D.Y., Westergard T.D., Kim H., Sasagawa S., Hsieh, J.J-D., Cheng E.H.-Y., The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc Natl Acad Sci USA 2009; 106:1093-1098.

Ren D., Kim H., Tu H., Westergard T.D., Fisher J.K., Rubens J.A., Korsmeyer S.J., Hsieh J.J.-D., Cheng E.H.-Y. The VDAC2-BAK Rheostat Controls Thymocyte Survival. Science Signaling 2009; 2: ra48.

Kim H., Tu H., Ren D., Takeuchi O., Jeffers J.R., Zambetti G.P., Hsieh J.J.-D., Cheng E.H.-Y. Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis. Molecular Cell 2009; 36:487-499.

Liu H., Takeda S., Kumar R., Westergard T.D., Brown E.J., Pandita T.K., Cheng E.H.-Y., Hsieh J.J.-D. Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint. Nature 2010; 467:343-346.

Ren D., Tu H., Kim H., Wang G.X., Bean G.R., Takeuchi O., Jeffers J.R., Zambetti G.P., Hsieh J.J.-D., Cheng, E.H.-Y. BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program. Science 2010; 330:1390-3.

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