The Park lab studies the molecular and cellular pathogenesis of hematopoietic disorders arising from hematopoietic stem/progenitor cells. We do so by directly comparing purified neoplastic hematopoietic stem/progenitor cells to their normal counterparts and interrogating their function in vivo and in vitro, using primary human cells whenever possible.
While in Irving Weissman's lab at Stanford, Dr. Park analyzed microRNA (miRNA) expression in purified human hematopoietic stem cells (HSC) and committed progenitors as well as leukemia-initiating cells, i.e. leukemia stem cells (LSC), in human acute myeloid leukemia (AML). These studies revealed widespread miRNA dysregulation in LSC compared to normal HSC/committed progenitors and resulted in the demonstration that miRNAs may act as oncogenes in human AML. Dr. Park's lab also investigates mechanisms underlying bone marrow failure syndromes, specifically myelodysplastic syndromes. Analysis of purified HSC and committed progenitors from MDS patients revealed widespread dysregulated mRNA expression in MDS, including numerous cell surface proteins and components of the ribosome biogenesis pathway.
Current areas of investigation include:
Pang WW, Pluvinage JV, Price EA, Sridhar K, Arber DA, Greenberg PL, Schrier SL, Park CY, Weissman IL. Hematopoietic stem cell and progenitor cell mechanisms in myelodysplastic syndromes. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3011-6. doi: 10.1073/pnas.1222861110. Epub 2013 Feb 6
McGowan KA, Pang WW, Bhardwaj R, Perez MG, Pluvinage JV, Glader BE, Malek R, Mendrysa SM, Weissman IL, Park CY, Barsh GS. Blood. Reduced ribosomal protein gene dosage and p53 activation in low-risk myelodysplastic syndrome. Blood. 2011 Sep 29;118(13):3622-33. doi: 10.1182/blood-2010-11-318584. Epub 2011 Jul 25.
Ooi AG, Sahoo D, Adorno M, Wang Y, Weissman IL, Park CY. MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21505-10. doi: 10.1073/pnas.1016218107. Epub 2010 Nov 30.
Han YC, Park CY, Bhagat G, Zhang J, Wang Y, Fan JB, Liu M, Zou Y, Weissman IL, Gu H. microRNA-29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J Exp Med. 2010 Mar 15;207(3):475-89. doi: 10.1084/jem.20090831. Epub 2010 Mar 8.
Park CY, Majeti R, Weissman IL. In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood. Nat Protoc. 2008;3(12):1932-40. doi: 10.1038/nprot.2008.194.
Clinical Scientist, Doris Duke Foundation (2012)
Scholar, American Federation of Aging Research (2011)
New Investigator Award, DOD Bone Marrow Failure Research Program (2011)
Fellow Scholar Award in Basic Research, American Society of Hematology (2009)
K08 Mentored Clinical Scientist Research Career Development Award, National Institutes of Health/National Cancer Institute (2007)
PhD with highest distinction, Columbia University College of Physicians and Surgeons (2001)
Titus Munson Coan Prize for best essay in the biological sciences, Columbia University College of Physicians and Surgeons (2001)
Young Investigator Award, Joint Meeting of the International Society for Interferon and Cytokine Research and the International Cytokine Society (1998)
Receive e-mail updates with the latest school news. Learn more ›