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GERSTNER SLOAN-KETTERING CORE COURSE TOPICS
FALL SEMESTER
Section 1 - Genome Biology
- Cancer as a disease
- Chemistry and structure of mutations
- Informational content of mutations and screening for mutations
- Chromosome structure
- Chromosome replication
- Drug discovery and development
- Topoisomerase poisons and nucleoside metabolism effectors as chemotherapeutic agents
- Linkage analysis
- Forward and reverse genetics
- Meiotic recombination
- Biochemical mechanisms of homologous recombination
- Double-strand break repair and non-homologous end joining
- Cytogenetics and cancer
- Healing DNA/RNA ends and sealing DNA/RNA strands
- DNA repair
- Chromosome segregation
- Chemical biology and chemotherapy of mitotic poisons
Section II - Proteins and Gene Expression
- Protein structure, folding, and modification
- Protein structure-function analysis
- Protein-protein and protein-DNA interactions
- Errors in protein folding and cancer
- Mechanics of translation
- RNA modification
- Computational and systems biology
- Mechanics of transcription
- Methods of experimental perturbation of gene expression and function in culture
- Gene transfer vectors: experimental and medical applications
- Clinical manipulation of gene expression
- Mouse model systems
- Measurement of gene expression
- Epigenetics
Section III - Cells and Regulation of the Cell Cycle
- Cellular membrane structure and function
- Cytoskeletal architecture
- Visualization of cells and cellular components
- Nuclear cytoplasmic export and import
- Mitochondria and endoplasmic reticulum
- The secretory pathway and endocytosis
- The cell cycle
- The mitotic checkpoint
- The DNA damage response
- Apoptosis
- p53
- Radiation as a therapeutic agent
- Current pharmocology of neoplastic agents
- Exploitation of checkpoints in chemotherapy
- Phase I design principles: Exploitation of checkpoints in chemotherapy
- Evolution of preatment protocols
SPRING SEMESTER
Section IV - Signaling and Development
- Principles of signal transduction and links to oncogenesis
- Introduction to signaling and cell type specification in development
- Gastrulation and early morphogenesis in drosophila
- Gastrulation and early morphogenesis in mammals
- The Ras and MAP kinase pathways: Normal functions in development
- The Ras and MAP kinase pathways in disease
- Wnt--the pathway and its normal functions in development
- Wnt and cancer
- TGFb signaling pathway
- TGFb signaling pathways in development
- TGFb signaling pathway in disease
- Hedgehog in development
- Hedgehog and cancer
- Notch
- Crosstalk between signaling pathways
- Transcription factors in development and cancer
- Growth control: Akt-Pten-Tor
- mTor and rapamycin
- Cell-to-Cell Adhesion and Communication
- Cell matrix adhesion and signaling
- Manipulating signal transductions pathways with small molecules
- Cell migration and invasion
- Stem cells
Section V - Cancer Immunology
- Overview of the immune system
- Innate immunity: NK cells
- Innate immunity: toll-like receptors
- Adaptive immunity -- B-cells
- Adaptive immunity -- T-cells: antigen presentation
- Adaptive immunity -- T-cells: antigen/MHC recognition and the TCR
- Adaptive immunity -- T-cells: T cell development
- Adaptive immunity -- T-cells: regulation of T cell activation
- Adaptive immunity -- T-cells: T cell effector responses and memory
- Tumor immunology: Immune system and cancer/immunotherapy of cancer
- Biostatistics
Section VI - Cancer Biology
- Basics of clinical trials
- Anatomic and molecular pathology
- Molecular imaging
- Pharmacology of chemotherapy drugs
- Targeting protein degradation (Hsp 90, etc)
- Radiation therapy principles
- Biomarkers
- Leukemia translocations
- Sarcoma translocations
- Molecular classification in lymphoma
- Kinases in myleproliferative diseases
- EGFR and Ras and lung cancer
- Kinases in glioblastoma
- B-Raf and melanoma
- Protesome inhibitors and myeloma
- Hormone-dependent cancers
- Colon cancer
- Inherited cancer susceptibility syndromes
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