This course meets three hours daily for 16 weeks during each of the fall and spring semesters. Topics are presented through a mix of didactic lecture and discussion oriented around papers from the research literature. Students present the papers in the discussion sections and are expected to lead discussions in their analysis.

The course is divided into six sections:

• Genome Biology, including genes and gene organization, chromosome biology, the maintenance of genomic integrity, and methods of manipulating genes.
• Proteins and Gene Expression, including proteins and their synthesis, enzymes and their mechanisms, protein structure and function, and regulation of gene expression.
• Cells and Regulation of the Cell Cycle, including cellular organization, cell cycle control, and cellular response to external and internal stimuli.
• Signaling and Development, including cell signaling pathways and mechanisms, cell differentiation, tissue formation, and organ development.
• Cancer Immunology, including antigen processing and presentation, innate and cognate immunity, immune surveillance, leukemia, and lymphoma.
• Cancer Biology, including the nature of evidence-based medicine, imaging, colon, breast, and prostate cancer, melanoma and immunotherapy, and clinical challenges.

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